Genomic analysis of indigenous goats in Southwest Asia reveals evidence of ancient adaptive introgression related to desert climate  

作　　者：Hojjat Asadollahpour Nanaei Yudong Cai Akil Alshawi Jiayue Wen Tanveer Hussain Wei-Wei Fu Nai-Yi Xu Abdulameer Essa Johannes ALenstra Xihong Wang Yu Jiang 

机构地区：[1]Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China [2]Department of Internal and Preventive Medicine,College of Veterinary Medicine,University of Baghdad,Iraqi Ministry of Higher Education and Scientific Research,Bagdad 10090,Iraq [3]Department of Molecular Biology,Virtual University of Pakistan,Lahore 54000,Pakistan [4]Animal Genetics Resources Department,Directorate of Animal Resources,the Ministry of Iraqi Agriculture,Baghdad 10081,Iraq [5]Faculty of Veterinary Medicine,Utrecht University,3508 TD Utrecht,The Netherlands

出　　处：《Zoological Research》2023年第1期20-29,共10页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China(32050410304,32002140,31822052,91431572381);National Thousand Youth Talents Plan to Y.J。

摘　　要：Understanding how evolutionary pressures related to climate change have shaped the current genetic background of domestic animals is a fundamental pursuit of biology. Here, we generated wholegenome sequencing data from native goat populations in Iraq and Pakistan. Combined with previously published data on modern, ancient(Late Neolithic to Medieval periods), and wild Capra species worldwide, we explored the genetic population structure, ancestry components, and signatures of natural positive selection in native goat populations in Southwest Asia(SWA). Results revealed that the genetic structure of SWA goats was deeply influenced by gene flow from the eastern Mediterranean during the Chalcolithic period, which may reflect adaptation to gradual warming and aridity in the region. Furthermore, comparative genomic analysis revealed adaptive introgression of the KITLG locus from the Nubian ibex(C. nubiana) into African and SWA goats. The frequency of the selected allele at this locus was significantly higher among goat populations located near northeastern Africa. These results provide new insights into the genetic composition and history of goat populations in the SWA region.

关 键 词：GOAT Adaptation KITLG Southwest Asia Nubian ibex 

分 类 号：Q95[生物学—动物学]