前列环素、神经肽Y与子痫前期关系及对胎盘早剥的预测价值研究  

Relationship between prostacyclin,neuropeptide Y and preeclampsia and their predictive value for placental abruption

作　　者：李文婷[1] 赵荣 LI Wenting;ZHAO Rong(Department of Obstetrics the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二附属医院产科,陕西咸阳712000 [2]安康市妇幼保健院妇产科,陕西安康725000

出　　处：《陕西医学杂志》2023年第2期145-148,175,共5页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(2021SF-312)。

摘　　要：目的:探讨前列环素、神经肽Y与子痫前期的关系及对胎盘早剥的预测价值。方法:选择120例子痫前期孕妇作为观察组,另选同期的120例正常妊娠孕妇作为对照组。比较两组血清前列环素、神经肽Y水平,分析前列环素、神经肽Y在不同严重程度的子痫前期孕妇中差异性,使用受试者工作特征曲线(ROC)分析前列环素联合神经肽Y对胎盘早剥的预测价值。结果:观察组血清前列环素水平低于对照组,神经肽Y水平高于对照组,两组比较差异均有统计学意义(均P<0.05);重度子痫前期组血清前列环素水平低于轻度子痫前期组,神经肽Y水平高于轻度子痫前期组,两组比较差异均有统计学意义(均P<0.05);经Pearson相关性分析,子痫前期孕妇24 h尿蛋白定量、血液黏度、红细胞压积与前列环素呈负相关(均P<0.05),与神经肽Y呈正相关(均P<0.05),血红蛋白、血小板计数与前列环素呈正相关(均P<0.05),与神经肽Y呈负相关(均P<0.05);经ROC曲线分析,血清前列环素联合神经肽Y预测子痫前期孕妇发生胎盘早剥的AUC为0.914。结论:子痫前期孕妇血清前列环素表达下调,神经肽Y表达上调,可能参与病情进展,两者联合预测胎盘早剥的效能较好。Objective:To analyze the relationship between prostacyclin,neuropeptide Y and preeclampsia and their predictive value for placental abruption.Methods:A total of 120 pregnant women with preeclampsia were selected as the observation group,and 120 normal pregnant women in the same period were selected as the control group.The serum levels of prostacyclin and neuropeptide Y were compared between the two groups,and the differences of prostacyclin and neuropeptide Y in pregnant women with different severity of preeclampsia were analyzed.The predictive value of prostacyclin combined with neuropeptide Y in placental abruption was analyzed by receiver operating characteristic(ROC)curve.Results:The level of prostacyclin in the observation group was lower than that in the control group,and the level of neuropeptide Y was higher than that in the control group(all P<0.05).The level of serum prostacyclin in severe preeclampsia group was lower than that in mild preeclampsia group,and the level of neuropeptide Y was higher than that in mild preeclampsia group(all P<0.05).Pearson correlation analysis showed that 24-hour urine protein quantification,blood viscosity and hematocrit were negatively correlated with prostacyclin and positively correlated with neuropeptide Y(all P<0.05);hemoglobin and platelet count were positively correlated with prostacyclin,and negatively correlated with neuropeptide Y(all P<0.05).ROC curve analysis showed that the AUC of serum prostacyclin c ombined with neuropeptide Y in predicting placental abruption in preeclamptic women was 0.914.Conclusion:The down-regulation of prostacyclin and neuropeptide Y in preeclampsia may be involved in the progression of the disease,the combination of prostacyclin and neuropeptide Y is effective in predicting placental abruption.

关 键 词：子痫前期 前列环素 神经肽Y 严重程度 胎盘早剥 预测价值 

分 类 号：R714.24[医药卫生—妇产科学]