肺结核合并艾滋病患者调整抗结核方案的影响因素分析  

Analysis of Factors Influencing the Adjustment of Anti-tuberculosis Regimen in Patients with Pulmonary Tuberculosis Combined with AIDS

作　　者：李晓娟 李业明 张九进 LI Xiaojuan;LI Yeming;ZHANG Jiujin(Department of Tuberculosis,Yulin Hospital,Affiliated to Youjiang Ethnic Medical College,Yulin,Guangxi Zhuang Autonomous Region,537000 China)

机构地区：[1]右江民族医学院附属玉林医院结核科,广西玉林537000

出　　处：《系统医学》2022年第21期114-117,共4页Systems Medicine

基　　金：玉林市科学研究与技术开发计划项目(20220649)。

摘　　要：目的 探讨肺结核合并艾滋病患者住院期间调整抗结核方案的独立影响因素。方法 回顾性分析2019年1月—2021年6月右江民族医学院附属玉林医院收治的80例肺结核合并艾滋病患者的临床资料,以住院期间是否调整HRZE抗结核方案分为调整组(37例)和未调整组(43例),分析两组的临床资料,找出患者调整抗结核方案的影响因素。结果 多因素Logistic回归分析显示,药物不良反应分级3~4级、消化道反应、肝功能损害是肺结核合并艾滋病患者住院期间调整抗结核药物方案的独立危险因素(OR=13.790、10.540、52.410,P<0.05)。结论 肺结核合并艾滋病患者在抗结核治疗时,3级以上药物不良反应、消化道反应、肝功能损害是患者调整抗结核方案的主要原因。Objective To explore the independent influencing factors of adjusting the anti-tuberculosis regimen in patients with pulmonary tuberculosis combined with AIDS during hospitalization. Methods The clinical data of 80 patients with pulmonary tuberculosis combined with AIDS admitted to Yulin Hospital, Affiliated to Youjiang Ethnic Medical College from January 2019 to June 2021 were retrospectively analyzed. They were divided into adjusted group(37 cases) and unadjusted group(43 cases) by whether the HRZE anti-tuberculosis regimen was adjusted during hospitalization. The clinical data of the two groups were analyzed to find out the influencing factors of patients’ adjustment of the anti-tuberculosis regimen. Results Multi-factor Logistic regression analysis showed that grade 3-4 adverse drug reaction, gastrointestinal reaction, and liver function impairment were independent risk factors for adjustment of anti-tuberculosis drug regimen during hospitalization in patients with pulmonary tuberculosis combined with AIDS(OR=13.790, 10.540, 52.410, P<0.05). Conclusion Grade 3 or higher adverse drug reaction, gastrointestinal reactions, and hepatic impairment were the main reasons for adjusting the anti-tuberculosis regimen in patients with pulmonary tuberculosis combined with AIDS during anti-tuberculosis treatment.

关 键 词：肺结核 艾滋病 抗结核药物 危险因素 

分 类 号：R521[医药卫生—内科学]