P-ANCA抗体阳性的类风湿关节炎血清学特点分析  

Serological analysis of positive P-ANCA in rheumatoid arthritis

作　　者：马杰桃 李珉珉[2] MA Jietao;LI Minmin(The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China;The First Affiliated Hospital of Jinan University,Guangzhou 510630,China)

机构地区：[1]广州医科大学附属第二医院,广州510260 [2]暨南大学附属第一医院,广州510630

出　　处：《广州医药》2023年第1期39-43,共5页Guangzhou Medical Journal

摘　　要：目的分析抗中性粒细胞胞浆抗体(ANCA)阳性类风湿关节炎(RA)患者的临床及血清学特征。方法回顾性比较分析2019—2020年本院住院113例核周型抗中性粒细胞胞浆抗体(P-ANCA)阳性及120例P-ANCA阴性RA患者的临床及实验室资料。结果P-ANCA阳性组的抗环瓜氨酸肽(CCP)抗体为(171.47±130.48)U/mL,阴性组为(130.10±132.7)U/mL,t=2.250,P=0.026。阳性组的抗CCP抗体的阳性率为82/98(83.67%),阴性组为71/110(64.55%),χ^(2)=9.749,P=0.003。阳性组CCP抗体高滴度率63/98(64.29%),阴性组为53/110(48.18%),χ^(2)=5.449,P=0.025。阳性组的RF浓度:(205.14±276.08)U/mL,阴性组RF浓度:(136.94±201.51)U/mL,t=2.159,P=0.032;阳性组的RF阳性率为98/112(87.5%),阴性组的78/120(65.89%),χ^(2)=16.016,P<0.001;阳性组的类风湿因子高浓度率73/112(64.60%),阴性组56/120(46.67%),χ^(2)=8.042,P=0.005。结论P-ANCA阳性的RA患者的抗体水平相对更高。Objective To analyze the clinical and serological characteristics of rheumatoid arthritis(RA)patients with positive anti-neutrophil cytoplasmic antibodies(ANCA).Methods The clinical and laboratory data of 113 perinuclear-ANCA(P-ANCA)positive and 120 P-ANCA negative RA patients in our hospital from 2019 to 2020 were retrospectively analyzed.Results The anti-cyclic citrullinated peptide(CCP)antibody of P-ANCA positive group was(171.47±130.48)U/mL,and which in the negative group was(130.10±132.7)U/mL,t=2.250,P=0.026.The positive rate of anti-CCP antibodies in positive group was 83.67%(82/98),and that in the negative group was 64.55%(71/110),χ^(2)=9.749,P=0.003.The high titre rate of CCP antibody in positive group was 64.29%(63/98),and that in the negative group was 53/110(48.18%),χ^(2)=5.449,P=0.025.The RF concentration of positive group was(205.14±276.08)U/mL,the negative group concentration was(136.94±201.51)U/mL,t=2.159,P=0.032;the RF-positive rate of positive group was 87.5%(98/112),65.89%(78/120)in the negative group,χ^(2)=16.016,P<0.001;the high concentration rate of rheumatoid factor in positive group was 73/112(64.60%),the negative group 56/120(46.67%),χ^(2)=8.042,P=0.005.Conclusions RA patients with positive P-ANCA had relatively higher antibody levels.

关 键 词：类风湿关节炎 抗中性粒细胞胞浆抗体 

分 类 号：R593.22[医药卫生—内科学] R446.6[医药卫生—临床医学]