透明质酸钠注射联合富含血小板的血浆治疗膝骨关节炎患者的疗效  

Efficacy of sodium hyaluronate injection combined with platelet-rich plasma in patients with knee osteoarthritis

作　　者：沙明 李慧锋 马松鹤[3] 张建军 SHA Ming;LI Huifeng;MA Songhe;ZHANG Jianjun(Surgical Department,Xuchang Yuanrong Neck,Shoulder,Lumbocrural Pain Hospital,Xuchang 461000,China;Pain Department,Zhengzhou Jihua Orthopedic Hospital,Zhengzhou 450000,China;Pain Department,Henan Provincial People s Hospital,Zhengzhou 450000,China;Orthopedics Department,Zhengzhou People s Hospital,Zhengzhou 450000,China)

机构地区：[1]许昌圆融颈肩腰腿痛医院外科,许昌461000 [2]郑州济华骨科医院疼痛科,郑州450000 [3]河南省人民医院疼痛科,郑州450000 [4]郑州人民医院骨科,郑州450000

出　　处：《广州医药》2023年第1期44-47,55,共5页Guangzhou Medical Journal

摘　　要：目的探讨透明质酸钠注射联合富含血小板的血浆治疗膝骨关节炎患者的效果。方法收集2019年7月—2021年7月在本院就诊的膝骨关节炎患者120例,采用随机数字表法分组,即对照组、观察组,均60例。对照组患者注入富含血小板的血浆(4 mL),观察组患者注射透明质酸钠(2 mL)联合富含血小板的血浆(3.5 mL),1次/周,3次为1个疗程,共2~3疗程。统计2组患者膝关节功能、临床疗效及并发症发生率。结果①组内比较:治疗后2月、3月及6月平均Lysholm膝关节评分均升高,P<0.05;②组间比较:治疗前及治疗后2月,2组患者平均Lysholm膝关节评分比较,P>0.05,治疗后3月、6月,2组平均Lysholm膝关节评分比较,P<0.05。2组患者Lysholm膝关节评分均较治疗前有所改善,P<0.05;观察组疼痛评分(18.92±4.11、17.61±3.83)分、肿胀度评分(10.64±2.82、9.66±1.21)分均高于对照组疼痛评分(14.02±3.52、13.54±3.21)分、肿胀度评分(9.62±2.63、8.71±1.93)分(P<0.05)。观察组临床总有效率98.33%高于对照组临床总有效率88.33%(χ^(2)=4.821,P=0.028)。经过6个月的随访后,2组均1例出现局部肿胀,未发生其他并发症。结论透明质酸钠注射联合富含血小板的血浆治疗膝骨关节炎患者,可以有效改善患者膝关节功能,减轻患者疼痛及肿胀程度等,安全性高,值得推广应用。Objective To investigate the effect of sodium hyaluronate injection combined with platelet-rich plasma in the treatment of patients with knee osteoarthritis.Methods A total of 120 patients with knee osteoarthritis who were treated in our hospital from July 2019 to July 2021 were collected and randomly divided into control group and observation group,60 cases each.The patients in the control group were injected with platelet-rich plasma(4 mL),and the patients in the observation group were injected with sodium hyaluronate(2 mL)combined with platelet-rich plasma(3.5 mL),once a week,3 times as a course of treatment,total 2-3 courses of treatment.The knee joint function,clinical efficacy and complication rates of the two groups were compared.Results①Intra-group comparison:the average Lysholm knee joint scores were significantly increased in 2 months,3 months and 6 months after treatment,P<0.05.②Comparison between groups:before and 2 months after treatment,the average Lysholm knee joint scores of the two groups were significantly increased(P<0.05).After 3 months and 6 months treatment,the comparison of the average Lysholm knee score between the two groups were statistic significant(P<0.05).The Lysholm knee joint scores in both groups were improved compared with those before treatment(P<0.05).Three months after treatment,the pain score(18.92±4.11,17.61±3.83)and swelling score(10.64±2.82,9.66±1.21)in the observation group were significantly higher than those in the control group(14.02±3.52,13.54±3.21,9.62±2.63,8.71±1.93,P<0.05).The total clinical effective rate of the observation group was 98.33%,which was significantly higher than that of the control group(88.33%,χ^(2)=4.821,P=0.028).After 6-month follow-up,local swelling occurred in 1 case in both groups,and no other complications occurred.Conclusions Sodium hyaluronate injection combined with platelet-rich plasma in the treatment of patients with knee osteoarthritis can effectively improve the knee joint function and reduce the pain and swelling of the pa

关 键 词：膝骨关节炎 透明质酸钠 富含血小板的血浆 膝关节 安全性 

分 类 号：R684.3[医药卫生—骨科学]