New perspective of skeletal stem cells  

作　　者：Guixin Yuan Zan Li Xixi Lin Na Li Ren Xu 

机构地区：[1]The First Affiliated Hospital of Xiamen University-ICMRS Collaborating Centre for Skeletal Stem Cell,State Key Laboratory of Cellular Stress Biology,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen,Fujian Province,China [2]Xiamen Key Laboratory of Regeneration Medicine,Fujian Provincial Key Laboratory of Organ and Tissue Regeneration,School of Medicine,School of Medicine,Xiamen University,Xiamen,Fujian Province,China [3]Department of Human Anatomy,School of Medicine,Xiamen University,Xiamen,Fujian Province,China [4]Department of Sports Medicine&Research Centre of Sports Medicine,Xiangya Hospital,Central South University,Changsha,Hunan Province,China

出　　处：《Biomaterials Translational》2022年第4期280-294,共15页生物材料转化电子杂志（英文）

基　　金：This work was supported in part by National Key R&D Program of China,No.2020YFA0112900(to RX);National Natural Science Foundation of China,Nos.81972034,92068104(to RX),82002262(to NL);Natural Science Foundation of Fujian Province,No.2022J06003(to RX).

摘　　要：Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity.Among these tissue-resident stem cells,skeletal stem cells(SSCs)were discovered in the growth plate region through a combination of cell surface markers and lineage tracing series.With the process of unravelling the anatomical variation of SSCs,researchers were also keen to investigate the developmental diversity outside the long bones,including in the sutures,craniofacial sites,and spinal regions.Recently,fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing have been used to map lineage trajectories by studying SSCs with different spatiotemporal distributions.The SSC niche also plays a pivotal role in regulating SSC fate,such as cell-cell interactions mediated by multiple signalling pathways.This review focuses on discussing the spatial and temporal distribution of SSCs,and broadening our understanding of the diversity and plasticity of SSCs by summarizing the progress of research into SSCs in recent years.

关 键 词：bone repair endochondral ossification growth plate lineage tracing skeletal stem cells 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]