钒化合物的靶点蛋白及其生物效应  

Protein Targets of Vanadium Compounds and Their Biological Effects

作　　者：杨雪 张铄 黄东娜 赵琳 王婉盈 王宇传 Yang Xue;Zhang Shuo;Huang Dongna;Zhao Lin;Wang Wanying;Wang Yuchuan(Hebei Key Laboratory for Chronic Diseases,School of Basic Medical Sciences,North China University of Science and Technology,Tangshan,063210;Shenzhen Second People’s Hospital,Shenzhen,518035)

机构地区：[1]华北理工大学基础医学院、河北省慢性疾病重点实验室,唐山063210 [2]深圳市第二人民医院,深圳518035

出　　处：《化学通报》2023年第1期12-22,共11页Chemistry

基　　金：河北省高校基本科研业务费(JQN2022026)资助。

摘　　要：作为一种生物相关的金属元素,基于钒的金属化合物在糖尿病、癌症、阿尔茨海默症、神经炎症等疾病的治疗方面表现出独特的潜在应用价值。现阶段研究表明,钒发挥其生物活性主要源于钒酸根作为磷酸根类似物对细胞内磷酸转移反应的影响,及钒在细胞内经氧化还原转化产生的活性氧物质对相关信号通路的调节;而钒化合物与细胞内靶点蛋白的相互作用亦被认为是发挥其治疗作用的关键因素。本文就钒的化学性质、钒化合物与血清蛋白的结合、钒化合物对细胞内效应靶点蛋白及其作用通路的调控、细胞内金属药物靶点蛋白分析鉴定等几方面,对近年来取得的相关研究的进展进行综述,以系统性阐释钒化合物用于疾病治疗的生物活性机制,并对进一步揭示钒化合物作用机理的探索方向及其药用前景进行展望。Being a biological relevant element, vanadium-based therapeutic compounds have shown unique potential application value in the treatment of different types of diseases such as diabetes, cancer, Alzheimer’s disease and neuroinflammation. Research progresses at current stage indicate that, the biological effects exerted by vanadium is mainly due to the influence of vanadate as a phosphate analogue on the intracellular phosphate transfer reaction, as well as the regulation effect of reactive oxygen species produced by the redox conversion of vanadium inside cells. The interactions of vanadium compounds with their intracellular target proteins are also considered to be a crucial factor in their therapeutic action. In this review, we summarize the chemical properties of vanadium, the research progresses in the interactions of vanadium compounds with serum proteins, the regulations of vanadium compounds on their intracellular target proteins and the relevant signaling pathways, as well as the progresses in the identification of cellular metallodrug-binding proteins, in order to systematically reveal the bioactive mechanisms of vanadium compounds in disease treatment. The directions of further exploring the action mechanisms of vanadium compounds and their medicinal prospects are also discussed.

关 键 词：钒化合物 靶点蛋白 抗糖尿病效应 神经保护机制 金属蛋白质组学 

分 类 号：TQ460.1[化学工程—制药化工]