微波辅助高效合成N-(2,6-二硝基苯基)苯磺酰胺及其抑制种子萌芽活性的研究  

Microwave Assisted Efficient Synthesis of N-(2,6-dinitrophenyl) benzenesulfonamide and Its Inhibition on Soybean Seed Germination

作　　者：黄志友 李文胜 徐佳 李晓红 杨贤均 王业社 Huang Zhiyou;Li Wensheng;Xu Jia;Li Xiaohong;Yang Xianjun;Wang Yeshe(College of Urban and Rural Construction,Shaoyang University,Shaoyang,422000;Shaoyang City Sixteen Middle School,Shaoyang,422000;College of Chemistry,Central China Normal University,Wuhan,430079)

机构地区：[1]邵阳学院城乡建设学院,邵阳422000 [2]邵阳市第十六中学,邵阳422000 [3]华中师范大学化学学院,武汉430079

出　　处：《化学通报》2023年第1期111-116,1,共7页Chemistry

基　　金：湖南省自然科学基金青年项目(2021JJ40515);湖南省教育厅科学研究优秀青年项目(21B0677)资助。

摘　　要：本文通过微波辐射促进芳基亲核取代反应(SNAr)获得20个N-(2,6-二硝基苯基)苯磺酰胺,该方法操作简单、收率高、耗时短(87%~94%,12min)、底物适用的范围广。种子萌芽实验结果表明,化合物3a在50、25μmol/L处理时可完全抑制大豆萌芽,在15μmol/L时抑制活性优于先导化合物PM1和ABA。该结果可为发现新型脱落酸功能类似物提供参考。An efficient method of synthesizing N-(2,6-dinitrophenyl)benzenesulfonamide was developed under microwave-assisted aryl nucleophilic substitution reaction(S_(N)Ar). This method has the characteristics of simple operation, high efficiency and high yield, and is suitable for a wide range of substrates. Additionally, the soybean seed germination was inhibited overwhelmingly when treated with 3 a at the concentration of 50 μmol/L and 25 μmol/L. Furthermore, the inhibition activity of 3 a was higher than ABA and lead compound PM1 at 15 μmol/L. These results are useful for discovering novel abscisic acid functional analogues.

关 键 词：微波辐射 脱落酸功能类似物 N-(2 6-二硝基苯基)苯磺酰胺 抑制种子萌芽 

分 类 号：TQ246.3[化学工程—有机化工]