脐血胆红素水平对足月儿高胆红素血症的预测价值研究  

Study on the Predictive Value of Umbilical Cord Blood Bilirubin Level for Hyperbilirubinemia in Term Infants

作　　者：刘博 黄新宇 董静 LIU Bo;HUANG Xin-yu;DONG Jing(Heilongjiang Nursing College,Harbin,Heilongjiang,150086,China;不详)

机构地区：[1]黑龙江护理高等专科学校,黑龙江哈尔滨150086 [2]佳木斯大学附属第一医院,黑龙江佳木斯154002

出　　处：《中国初级卫生保健》2022年第12期106-108,共3页Chinese Primary Health Care

摘　　要：目的:分析脐血胆红素水平对足月儿发生高胆红素血症(NHB)的预测价值,旨在为预防NHB、胆红素脑病提供数据支持。方法:选取2021年1月—2022年1月某院产科出生的284名足月新生儿为研究对象,检测其血清总胆红素(TBIL)、脐胆红素水平,按照后期是否出现NHB,将其分为正常组(225人)和高胆红素组(59人)。采用Spearman分析、Pearson相关性分析足月儿脐血胆红素水平与TBIL、NHB发生率的相关性,探究脐血胆红素对NHB的预测价值。结果:高胆红素组足月儿脐血胆红素水平为(41.87±6.24)μmol/L,正常组为(32.98±6.81)μmol/L,两组比较,差异有统计学意义(t=13.109,P<0.05);TBIL水平为(4293.51±86.59)μmol/L,正常组为(131.28±44.06)μmol/L,两组比较,差异有统计学意义(t=27.753,P<0.05)。脐血胆红素水平与NHB发生率、血清TBIL水平均呈显著正相关(r值分别为0.538和0.649,P值均<0.05)。受试者工作特征曲线(ROC)显示,脐血胆红素水平预测NHB的ROC曲线下面积为0.841,95%CI为(0.769,0.847),最佳截断值为43.8μmol/L,其诊断的特异度、灵敏度分别为88.39%、73.91%。结论:脐血胆红素水平与足月儿NHB发生率呈正相关,脐血胆红素可用来预测NHB的发生。OBJECTIVE To analyze the predictive value of umbilical cord blood bilirubin level for NHB in term infants.METHODS 284 full-term newborns born in the obstetrics department of our maternal and child health hospital from January 2021 to January 2022 were selected.The serum TBIL and umbilical bilirubin levels were measured.According to whether there was NHB,they were divided into normal group and high bilirubin group.The umbilical blood bilirubin levels of the two groups were compared.Spearman analysis and Pearson analysis were used to evaluate the correlation between the umbilical blood bilirubin level and the incidence of serum TBIL and NHB,and to draw ROC curves,To explore the predictive value of umbilical cord blood bilirubin on NHB.RESULTS The umbilical blood bilirubin level wasμmol/L(41.87±6.24)and normal group(32.98±6.81)in the term group(t=13.109,P<0.05).TBIL level(4293.51±86.59)μmol/L and normal group(131.28±44.06),the two groups were statistically significant(t=27.753,P<0.05).Umbilical blood bilirubin levels were significantly positively correlated with NHB incidence and serum TBIL levels(r=0.538,0.649,P<0.05).The subject operating characteristic curve(ROC)showed that the area under the ROC curve of umbilical cord blood bilirubin level was 0.841(95%CI 0.769~0.847),with an optimal cutoff value of 43.8μmol/L,and the diagnostic specificity and sensitivity were 88.39%and 73.91%,respectively.CONCLUSION There is a positive correlation between cord blood bilirubin level and the incidence of NHB in term infants.Cord blood bilirubin can be used to predict the incidence of NHB.

关 键 词：高胆红素血症 脐血胆红素 足月儿 预测价值 

分 类 号：R722.1[医药卫生—儿科]