Ambient Fine Particulate Matter Exposure and Blood Pressure:Evidence from a Large Chinese Multiple Follow-Up Study  

作　　者：JIANGTULU Bahabaike LAN Chang Xin CHEN Jun Xi CHEN Xi WANG Bin XUE Tao 

机构地区：[1]Institute of Reproductive and Child Health,Key Laboratory of Reproductive Health,National Health Commission of the People's Republic of China,Beijing 100191,China [2]Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China [3]National Institute of Environmental Health,Chinese Center for Disease Control and Prevention(China CDC),Beijing 102206,China

出　　处：《Biomedical and Environmental Sciences》2023年第1期38-49,共12页生物医学与环境科学（英文版）

摘　　要：Objective This study aimed to investigate the association of ambient PM_(2.5)exposure with blood pressure(BP)at the population level in China.Methods A total of 14,080 participants who had at least two valid blood pressure records were selected from the China Health and Retirement Longitudinal Survey during 2011–2015.Their long-term PM_(2.5)exposure was assessed at the geographical level,on the basis of a regular 0.1°×0.1°grid over China.A mixed-effects regression model was used to assess associations.Results Each decrease of 10μg/m^(3)in the 1 year-mean PM_(2.5)concentration(FPM1Y)was associated with a decrease of 1.24[95%confidence interval(CI):0.84–1.64]mmHg systolic BP(SBP)and 0.50(95%CI:0.25–0.75)mmHg diastolic BP(DBP),respectively.A robust association was observed between the long-term decrease in PM_(2.5)and decreased BP in the middle-aged and older population.Using a generalized additive mixed model,we further found that SBP increased nonlinearly overall with FPM1Y but in an approximately linear range when the FPM1Y concentration was<70μg/m^(3);In contrast,DBP increased approximately linearly without a clear threshold.Conclusion Efficient control of PM_(2.5)air pollution may promote vascular health in China.Our study provides robust scientific support for making the related air pollution control policies.

关 键 词：Fine particulate matter PM_(2.5) Blood pressure Risk assessment Preventive medicine 

分 类 号：R122.26[医药卫生—环境卫生学]