能谱CT定量参数与肺癌临床病理参数关系及对预后的预测价值  

Study on the relationship between quantitative parameters of energy spectrum CT and clinicopathological parameters of lung cancer and the value of prognosis prediction

作　　者：石惠君 利娜[1] 刘平安 杜建文[2] SHI Huijun;LI Na;LIU Pingan;DU Jianwen(Department of Radiology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China;Department of Ultrasound Chengde Central Hospital,Chengde 067000,China)

机构地区：[1]河北省石家庄市中医院放射科,河北石家庄050000 [2]河北省承德市中心医院超声科,河北承德067000

出　　处：《医学影像学杂志》2023年第1期25-29,共5页Journal of Medical Imaging

基　　金：河北省医学科学研究课题计划项目(编号:20191301)。

摘　　要：目的 探讨能谱CT定量参数与肺癌临床病理参数关系及对预后的预测价值。方法 选取我院肺癌患者82例,根据病理结果82例肺癌患者设为观察组,同期82例肺炎性结节为对照组。检测不同临床病理参数、不同预后患者能谱CT定量参数和CT定量参数对肺癌患者生存率预测价值。结果 观察组NICVP、NICAP、ICD高于对照组,且观察组中病理类型为腺癌、浸润程度为T3+T4、有淋巴结转移患者NICVP、NICAP、ICD高于病理类型为鳞癌、浸润程度为T1+T2、无淋巴结转移患者(P<0.05);Spearman相关性分析可知,NICVP、NICAP、ICD与肺癌患者病理类型、浸润程度、淋巴结转移有关(P<0.05);2年死亡肺癌患者NICVP、NICAP、ICD高于2年生存患者(P<0.05);Logistic回归分析发现,NICVP、NICAP、ICD为2年死亡患者重要危险因素(P<0.05);绘制ROC曲线显示,NICVP、NICAP、ICD联合预测肺癌患者2年死亡的敏感度为80.95%,特异度为82.50%。结论 肺癌患者的能谱CT定量参数NICVP、NICAP、ICD较肺炎性结节患者增高,且与肺癌患者病理类型、浸润程度、有无淋巴结转移等临床病理参数有关。Objective To explore the relationship between the quantitative parameters of energy spectrum CT and the clinicopathological parameters of lung cancer and the predictive value of the prognosis of patients. Methods 82 patients with lung cancer in our hospital were selected as the malignant group, and 82 patients with pneumonic nodules during the same period were selected as the benign group. We detected the energy spectrum CT quantitative parameters [normalized iodine concentration in the venous phase(NICVP), normalized iodine concentration in the arterial phase(NICAP), normalized iodine concentration(ICD)] in different clinical pathological parameters and patients with different prognosis in the two groups and the malignant group. We explored the relationship between the quantitative parameters of energy spectrum CT and clinicopathological parameters of lung cancer patients and the influencing factors of lung cancer patients’ death in 2 years, and observed the predictive value of quantitative parameters of energy spectrum CT on lung cancer patients’ 2-year death. Results The NICVP, NICAP, and ICD in the malignant group were higher than those in the benign group. In patients with malignant group, the pathological type was adenocarcinoma, the degree of invasion was T3+T4, and the patients with lymph node metastasis had higher NICVP, NICAP, and ICD than those with pathological type of squamous cell carcinoma, T1+T2 infiltration degree, and no lymph node metastasis(P<0.05);Spearman correlation analysis showed that NICVP, NICAP, and ICD were related to the pathological type, degree of invasion, and lymph node metastasis of lung cancer patients(P<0.05);the NICVP, NICAP and ICD of lung cancer patients who died in 2 years were higher than those who survived in 2 years(P<0.05);Logistic regression analysis found that NICVP, NICAP, and ICD were important risk factors for patients who died within 2 years(P<0.05);plotting ROC curve showed that the sensitivity of NICVP, NICAP, and ICD in predicting 2-year mortality of lung

关 键 词：体层摄影术 X线计算机 肺癌 临床病理参数 

分 类 号：R814.42[医药卫生—影像医学与核医学] R734.2[医药卫生—放射医学]