Meta-analysis on Efficacy and Safety of Compound Stomachache Inflammation Caused by Helicobacter Pylori  

作　　者：LAI Su-yu XI Jun-yu LYU Jian SHI Bu-wen XIE Yan-ming 赖素玉;席俊羽;吕健;史卜文;谢雁鸣(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China [2]Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China [3]Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2022年第6期1-10,共10页世界中西医结合杂志（英文）

基　　金：National Key R&D Plan"Research on Modernization of Traditional Chinese Medicine"(2018YFC1707400)。

摘　　要：Objective:To systematically evaluate the efficacy and safety of Compound Stomachache Capsule(复方胃痛胶囊)in the treatment of digestive ulcer and inflammation Helicobacter pylori-Peptic Ulcer(Hp-PU)caused by Helicobacter pylori(Hp).Methods:Randomized controlled trials(RCTs)of Compound Stomachache Capsule(复方胃痛胶囊)in the treatment of Hp-PU were screened out by searching CNKI,VIP,Wanfang,China Biomedical Literature Service System,Cochrane Library,Pub Med,EMbase,Web of Science and Clinical Trials.gov.Meta-analysis was performed with Rev Man 5.4 software.Results:Three RCTs were included,including 331 patients of 166 patients in the experimental group(Compound Stomachache Capsule(复方胃痛胶囊)+conventional western medicine treatment)and 165 patients in the control group(conventional western medicine treatment).Meta-analysis data showed that Hp eradication rate(RR=1.10,95%CI[1.01-1.19],P=0.03)was significantly higher in the experimental group than in the control group.The experimental group was superior to the control group in improving clinical symptoms(RR=1.59,95%CI[1.22-2.06],P=0.0006).Conclusion:According to the current evidence,the Compound Stomachache Capsule(复方胃痛胶囊)combined with conventional Western medicine treatment can improve the Hp eradication rate of Hp-PU,relieve symptoms,and do not increase the incidence of adverse reactions.However,the number of included studies is small and the sample size is small,so its effectiveness and safety need further verification.

关 键 词：Dystematic evaluation Compound Stomachache Capsule(复方胃痛胶囊) Helicobacter Pylori(Hp) Peptic ulcer(PU) Digestive system inflammation Randomized controlled trial(RCTs) Effectivity Safety META-ANALYSIS 

分 类 号：R259[医药卫生—中西医结合]