Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content  

作　　者：Jiawei Shi Mingsheng Li Huajun Tang Jiqiang Kang Najia Sharmin Amir Rosenthal Kenneth K.Y.Wong 

机构地区：[1]Department of Electrical and Electronic Engineering,The University of Hong [2]Kong,Pokfulam Road,Hong Kong,China.2 Department of Electrical Engineering,Technion–Israel Institute of Technology,Technion City,32000 Haifa,Israel [3]Advanced Biomedical Instrumentation Centre,Hong Kong Science Park,Shatin,New Territories,Hong Kong,China

出　　处：《eLight》2022年第1期68-74,共7页e光学（英文）

基　　金：This project is funded by Research Grants Council of the Hong Kong Special Administrative Region,China(HKU 17200219,HKU 17209018,E-HKU701/17,CityU T42-103/16-N,and HKU C7047-16G);Natural Science Foundation of China(N_HKU712/16)。

摘　　要：Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively,such as leveraging the vibrational absorption peak of the O-H bond.However,due to the lack of an efficient laser source,it was challenging to image the water content in the deep tissue with micron-level spatial resolution.To address this problem,we develop a high-power hybrid optical parametrically-oscillating emitter(HOPE)at 1930 nm,at which the vibrational absorption peak of the O-H bond locates.The maximum pulse energy is over 1.74μJ with a pulse repetition rate of 50 kHz and a pulse width of 15 ns.We employ this laser source in the optical-resolution photoacoustic microscopy(OR-PAM)system to image the water content in the phantom and the biological tissue in vitro.Our 1930-nm OR-PAM could map the water content in the complex tissue environment at high spatial resolution,deep penetration depth,improved sensitivity,and suppressed artifact signal of the lipid.

关 键 词：Fiber optical parametric oscillator Thulium-doped fiber laser Photoacoustic microscopy 

分 类 号：O43[机械工程—光学工程]