TgAb、Tg、TSH水平对临床鉴别诊断良恶性甲状腺结节的价值  

The Value of Serum Anti-Thyroglobulin Antibody,Thyroglobulin and Thyrotropin in Clinical Differential Diagnosis of Benign and Malignant Thyroid Nodules

作　　者：谢美华[1] 黄河[1] 李肇暖[1] XIE Meihua;HUANG He;LI Zhaonuan(Department of Laboratory,Sanming Second Hospital,Sanming Fujian 366000,China)

机构地区：[1]三明市第二医院检验科,福建三明366000

出　　处：《中国卫生标准管理》2022年第24期75-79,共5页China Health Standard Management

摘　　要：目的探讨血清抗甲状腺球蛋白抗体(thyroglobulin antibody,TgAb)、甲状球蛋白(thyroglobulin,Tg)及促甲状腺激素(thyroid-stimulating hormone,TSH)水平在良恶性甲状腺结节中的临床鉴别诊断价值。方法选择三明市第二医院2021年1月—2022年1月甲状腺结节97例,以病理结果分为良性组(n=76)和恶性组(n=21)。采用电化学发光法检测两组TgAb和Tg水平;采用化学发光法测定两组TSH水平。比较TgAb、Tg、TSH水平与TgAb、Tg及联合阳性率;绘制受试者工作特征曲线(receiver operating characteristic curve,ROC曲线),分析TgAb、Tg、TSH及联合在良恶性甲状腺结节中的鉴别效能。结果恶性组TgAb、Tg及TSH水平均高于良性组(P<0.05)。恶性组TgAb、Tg、TgAb+Tg阳性率高于良性组(P<0.05)。ROC曲线结果表明,TgAb、Tg及TSH联合检测用于良恶性甲状腺结节患者中的诊断鉴别灵敏度、特异度高于单一TgAb、Tg及TSH指标。结论TgAb、Tg及TSH在恶性甲状腺结节中表达异常,且甲状腺恶性结节患者常伴有TgAb联合Tg阳性率升高,三者联合检测能获得较高的鉴别诊断效能,可为临床诊疗提供参考依据。Objective To investigate the clinical differential diagnostic value of serum anti thyroglobulin antibody(TgAb),thyroglobulin(Tg)and thyroid stimulating hormone(TSH)levels in benign and malignant thyroid nodules.Methods A total of 97 cases of thyroid nodules from January 2021 to January 2022 in Sanming Second Hospital were selected.The pathological results were divided into benign group(n=76)and malignant group(n=21).The levels of TgAb and Tg in the two groups were detected by electrochemiluminescence method.The levels of TSH in the two groups were measured by chemiluminescence method,and the levels of TgAb,Tg,TSH,TgAb,Tg and their combined positive rates were compared.Draw receiver operating characteristic curve(ROC curve for short),and analyze the differentiation efficiency of TgAb,Tg,TSH and their combination in benign and malignant thyroid nodules.Results The levels of TgAb,Tg and TSH in malignant group were higher than those in benign group(P<0.05).The positive rates of TgAb,Tg,TgAb+Tg in malignant group were higher than those in benign group(P<0.05).The results of ROC curve showed that the sensitivity and specificity of combined detection of TgAb,Tg and TSH in the diagnosis of benign and malignant thyroid nodules were higher than those of single TgAb,Tg and TSH.Conclusion The expression of TgAb,Tg and TSH is abnormal in malignant thyroid nodules,and patients with malignant thyroid nodules are often accompanied by an increase in the positive rate of TgAb combined with Tg.The combined detection of the three can obtain higher differential diagnostic efficacy,which can provide a reference for clinical diagnosis and treatment.

关 键 词：抗甲状腺球蛋白抗体 甲状球蛋白 促甲状腺激素 良、恶性 甲状腺结节 鉴别诊断 

分 类 号：R446[医药卫生—诊断学]