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作 者:章练锋 陈德俊[1] ZHANG Lianfeng;CHEN Dejun(Department of Internal Medicine,Puning Overseas Chinese Hospital,Puning Guangdong 515300,China)
出 处:《中国卫生标准管理》2022年第24期125-128,共4页China Health Standard Management
摘 要:目的探讨沙库巴曲缬沙坦钠联合美托洛尔治疗顽固性心力衰竭的临床效果。方法选取2019年4月—2020年4月普宁华侨医院收治的顽固性心力衰竭患者80例,随机分为观察组与对照组,每组40例。两组患者均接受常规抗心衰系统治疗,在此基础上,对照组加用美托洛尔缓释片,观察组患者则接受沙库巴曲缬沙坦钠联合美托洛尔联合治疗。记录并比较两组患者治疗效果,使用明尼达心功能不全生活质量量表(Minnesota living with heart failure questionnaire,MLHFQ)对预后进行评价。结果治疗后观察组患者治疗总有效率(92.50%)显著高于对照组(72.50%),差异有统计学意义(P<0.05)。对照组与观察组患者的MLHFQ评分在入组后接受治疗前分别为(82.03±5.51)分、(81.02±4.52)分,差异无统计学意义(P>0.05)。治疗后,对照组与观察组患者评分分别为(63.34±2.96)分、(50.81±3.99)分,均低于治疗前,差异均有统计学意义(P<0.05)。治疗后,观察组MLHFQ评分低于对照组,差异有统计学意义(P<0.05)。结论沙库巴曲缬沙坦钠联合美托洛尔治疗顽固性心力衰竭的临床效果显著,并能通过改善心功能达到提升患者生活质量的目的,具有一定社会学和卫生学意义,值得推荐。Objective To explore the clinical effect of noxintuo combined with metoprolol in the treatment of refractory heart failure.Methods A total of 80 patients with refractory heart failure from April 2019 to April 2020 of Puning Overseas Chinese Hospital were divided into observation group and control group.All patients received conventional anti heart failure system treatment,on this basis,the control group was added with metoprolol sustained-release tablets,while the observation group was treated with combination of noxintuo and metoprolol.The treatment effects of the two groups were recorded and compared,and the prognosis was evaluated by Minnesota Living with Heart Failure Questionnaire(MLHFQ).Results After receiving different intervention measures,the total effective rate of treatment in the observation group(92.50%)was significantly higher than that in the control group(72.50%),and the difference was statistically significant(P<0.05).The MLHFQ scores of the control group and the observation group were(82.03±5.51)points,(81.02±4.52)points,respectively,and the difference was not statistically significant(P>0.05).After the treatment,the scores of patients in the control group and the observation group were(63.34±2.96)points,(50.81±3.99)points,respectively,which were lower than those before treatment,and the comparative differences were statistically significant(P<0.05).After treatment,the MLHFQ score was lower in the observation group than in the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical effect of noxintuo combined with metoprolol in the treatment of refractory heart failure is significant,and it can improve the quality of life of patients by improving cardiac function.It has certain sociological and hygienic significance and it is worthy of recommendation.
关 键 词:沙库巴曲缬沙坦钠 美托洛尔 心力衰竭 心功能 临床疗效 血管紧张素受体拮抗剂
分 类 号:R541[医药卫生—心血管疾病]
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