盐酸曲美他嗪联合阿托伐他汀钙治疗冠心病对患者心功能的影响  

Effects of Trimetazidine hydrochloride combined with Atorvastatin calcium on cardiac function in patients with coronary heart disease

作　　者：赵红[1] 李莹[1] 那世敬[1] 李博[1] ZHAO Hong;LI Ying;NA Shijing;LI Bo(Fourth Wards of Cardiology Department,Harbin The First Hospital,Harbin,Heilongjiang 150010,China)

机构地区：[1]哈尔滨市第一医院心内科四病房,黑龙江哈尔滨150010

出　　处：《现代医学与健康研究电子杂志》2023年第4期32-35,共4页Modern Medicine and Health Research

摘　　要：目的探讨盐酸曲美他嗪联合阿托伐他汀钙治疗冠心病对患者左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)水平的影响,以期为临床治疗冠心病提供参考依据。方法以随机数字表法将哈尔滨市第一医院2020年5月至10月期间收治的67例冠心病患者分为两组。对照组患者(33例)采用常规治疗+阿托伐他汀钙治疗,试验组患者(34例)在对照组的基础上联合盐酸曲美他嗪治疗,均治疗3个月。比较两组患者临床疗效,治疗前后LVESD、LVEDD、LVEF、血清心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶-MB(CK-MB)、氨基末端脑钠肽前体(NT-proBNP)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果治疗后试验组患者临床总有效率高于对照组;与治疗前比,治疗后两组患者LVESD、LVEDD水平、血清c TnI、CK-MB、NT-proBNP、TC、TG、LDL-C水平均降低,且试验组低于对照组,而LVEF、HDL-C水平均升高,试验组高于对照组(均P<0.05)。结论盐酸曲美他嗪联合阿托伐他汀钙治疗冠心病可改善患者心功能,促进心肌细胞代谢,改善血管内皮功能,同时调节血脂水平,提升临床治疗效果。Objective To investigate the effects of Trimetazidine hydrochloride combined with Atorvastatin calcium in the treatment of coronary heart disease on the levels of left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF),so as to provide reference for clinical treatment.Methods According to the random number table method,67 patients with coronary heart disease admitted to Harbin The First Hospital from May to October 2020 were divided into two groups.The patients in the control group(33 cases)were treated with conventional therapy+Atorvastatin calcium,the patients in the experimental group(34 cases)were treated with Atorvastatin calcium+Trimetazidine hydrochloride,both patients were treated for 3 months.Clinical efficacy after treatment,LVESD,LVEDD,LVEF,serum cardiac troponin I(cTnI),creatine kinase isoenzyme-MB(CK-MB),N-terminal pro-brain natriuretic peptide(NT-pro BNP),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)levels before and after treatment were compared between the two groups.Results After treatment,the clinical total effective rate of patients in the experimental group was higher than that in the control group;compared with before treatment,the levels of LVESD,LVEDD,serum c Tn I,CK-MB,NT-proBNP,TC,TG and LDL-C in the two groups decreased after treatment,the experimental group was lower than the control group,the levels of LVEF,HDL-C increased,the experimental group was higher than the control group(all P<0.05).Conclusion Trimetazidine hydrochloride combined with Atorvastatin calcium in the treatment of coronary heart disease can improve cardiac function,promote myocardial cell metabolism,improve vascular endothelial function,regulate blood lipid levels,and improve clinical therapeutic effects.

关 键 词：冠心病 盐酸曲美他嗪 阿托伐他汀钙 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]