慢性丙型肝炎患者基因分型与病毒载量、肝功能、抗体检测结果的相关性分析  

The Correlations of Genotype with Viral Load,Liver Function and Antibody Test Results Among Patients with Chronic Hepatitis C

作　　者：韩金育 金方方 韩莹 孟欢 陈瑾 王雅杰 HAN Jinyu;JIN Fangfang;HAN Ying;MENG Huan;CHEN Jin;WANG Yajie(Department of Clinical Laboratory,Peking University Ditan Teaching Haspital,Beijing 100015,China;Department of Clinical Labortoy,Beijing Ditan Hospital Affiliated to Capital Medical University,Beijing 100015,China)

机构地区：[1]北京大学地坛医院教学医院检验科,北京100015 [2]首都医科大学附属北京地坛医院检验科,北京100015

出　　处：《标记免疫分析与临床》2022年第11期1811-1815,共5页Labeled Immunoassays and Clinical Medicine

基　　金：吴阶平医学基金会临床科研专项资助基金(编号:320.6750.19089-75)。

摘　　要：目的分析慢性丙型肝炎患者丙型肝炎病毒(HCV)基因型分布概况,并探讨其与性别、年龄、病毒载量、肝功能、抗体检测结果的关系,为慢性丙型肝炎的诊疗提供实验室依据。方法通过回顾性研究,收集2020年1月至2021年12月就诊于首都医科大学附属北京地坛医院未经过治疗的247例慢性丙型肝炎患者一般临床资料、基因分型、丙型肝炎病毒核酸定量结果、肝酶[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)、白蛋白(ALB)]及丙型肝炎病毒抗体S/CO值,比较分析HCV不同基因型病毒载量、肝功能及丙型肝炎病毒抗体检测结果的差异。结果在247例慢性丙型肝炎患者中,1b型143例(57.9%)、2a型71例(28.7%)、3a型19例(7.7%)、3b型14例(5.7%),不同基因型性别、年龄、病毒载量、TBIL、DBIL、ALP、ALB差异无统计学意义(P>0.05),3a型、3b型ALT、AST水平显著高于1b型、2a型(P<0.05),3a型GGT水平显著高于1b型、2a型(P<0.05)。1b型丙型肝炎病毒抗体S/CO值显著高于2a型、3a型、3b型(P<0.001)。结论在本研究中,HCV感染以1b型为主,其次是2a型、3a型、3b型,不同基因型病毒载量、性别、年龄、TBIL、DBIL、ALP、ALB差异无统计学意义,ALT、AST、GGT、丙型肝炎病毒抗体检测结果差异具有统计学意义。Objective To study the genotype distribution of hepatitis C virus(HCV)and to investigate the relevance between hepatitis C virus genotyping and sex,age,viral load,liver function and antibody test results,and to provide a laboratory reference basis for the diagnosis and treatment of chronic hepatitis C.Methods A total of 247 untreated patients with CHC from January,2020 to December,2021 in Beijing Ditan Hospital Capital Medical University were analyzed retrospectively.We collected patients’clinical data,genotype,quantitative results of hepatitis C virus nucleic acid,liver enzyme[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),direct bilirubin(DBIL),alkaline phosphatase(ALP),γ-glutamyltrans-feraseand(GGT),albumin(ALB)]and HCV antibody S/CO ratio,and then the differences in the viral load,liver function and HCV antibody test results among these patients with different genotypes of hepatitis C virus were compared and analyzed.Results Among 247 patients with chronic hepatitis C,there were 143 cases of type 1b(57.9%),71 cases of type 2a(28.7%),19 cases of type 3a(7.7%),14 cases of type 3b(5.7%).The differences of sex,age,viral load,TBIL,DBIL,ALP and ALB among different genotypes were not statistically significant(P>0.05).ALT,AST levels of type 3a,type 3b were significantly higher than type 1b and type 2a(P<0.05).GGT level of type 3a was significantly higher than type 1b and type 2a(P<0.05).HCV antibody S/CO ratio of type 1b was significantly higher than type 2a,type 3a,and type 3b(P<0.001).Conclusion Hepatitis C virus infection in the current study is dominated by type 1b,followed by type 2a,type 3a,and type 3b.The differences of viral load,sex,age,TBIL,DBIL,ALP and ALB are not significant,while the differences of ALT,AST,GGT and HCV antibody test results are significant.

关 键 词：慢性丙型肝炎 基因型 病毒载量 肝功能 丙型肝炎病毒抗体S/CO值 

分 类 号：R512.63[医药卫生—内科学]