Adenylate cyclase activity of TIR1/AFB links cAMP to auxin-dependent responses  

作　　者：Aloysius Wong Xuechen Tian Yixin Yang Chris Gehring 

机构地区：[1]Department of Biology,College of Science and Technology,Wenzhou-Kean University,88 Daxue Road,Ouhai,Wenzhou 325060,Zhejiang Province,China [2]Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics,Ouhai,Wenzhou 325060,Zhejiang Province,China [3]Zhejiang Bioinformatics International Science and Technology Cooperation Center,Ouhai,Wenzhou 325060,Zhejiang Province,China [4]Department of Chemistry,Biology&Biotechnology,University of Perugia,Perugia 06121,Italy

出　　处：《Molecular Plant》2022年第12期1838-1840,共3页分子植物（英文版）

基　　金：A.W.is supported by the National Natural Science Foundation of China(32100581);the International Collaborative Research Program of Wenzhou-Kean University(ICRP202202).

摘　　要：The phytohormone auxin is essential for plant growth and development as well as cellular and systemic responses to environmental cues.The auxin receptor TRANSPORT INHIBITOR RESPONSE 1/AUXIN-SIGNALING F-BOX(TIR1/AFB)lies within an E3 ubiquitin ligase complex(SCF^(TIR1/AFB))consisting of Skp,Cullin,and F-box proteins.Auxin brings together TIR1/AFB and the transcriptional repressor Auxin/INDOLE-3-ACETIC ACID(Aux/IAA),which allows the SCF^(TIR1/AFB) complex to transfer activated ubiquitin to Aux/IAA,thereby targeting it for proteasomal degradation.This liberates the transcription factors AUXINRESPONSE FACTORs for auxin-dependent transcription(Lavy and Estelle,2016).

关 键 词：complex AFB of 

分 类 号：Q94[生物学—植物学]