职业性苯暴露生物标志物的研究进展  

Research progress on biomarkers of occupational benzene exposure

作　　者：李培[1] 王欣[1] 曾强[1] LI Pei;WANG Xin;ZENG Qiang(Department of Occupational Disease Prevention and Control,Tianjin Center for Disease Control and Prevention,Tianjin,300011,China)

机构地区：[1]天津市疾病预防控制中心职业病预防控制室,天津300011

出　　处：《职业与健康》2022年第22期3133-3137,3141,共6页Occupation and Health

基　　金：天津市卫生健康科技项目(KJ20186);天津市医学重点建设学科(TJYXZDXX-66B)。

摘　　要：苯广泛应用于工农业生产中,作为有机化学合成中常用的原料,全国约50万人从事接苯或含苯溶剂作业。1982年国际癌症研究中心将苯确定为Ⅰ类致癌物。苯危害严重,如何更好地保护广大职业苯暴露人群的健康和生命安全是当前职业卫生领域的重点工作之一。探索灵敏度高、特异性强且可行性好的生物标志物对于保护劳动者的职业健康具有重要意义。我们针对职业性苯暴露生物标志物研究进展进行综述,为苯暴露所致职业病的预防提供理论依据。Benzene is widely used in industrial and agricultural production.As a commonly used raw material in organic chemical synthesis,about 500000 people across the country are engaged in benzene or benzene-containing solvent operations.In 1982,the International Cancer Research Center identified benzene as a Class I carcinogen.Benzene is a serious hazard.How to better protect the health and life safety of the majority of occupational benzene-exposedworkers is one of the current key tasks in the field of occupational health.Exploring biomarkers with high sensitivity,high specificity and good feasibility is of great significance to protect the occupational health of workers.We review the research progress of biomarkers of occupational benzene exposure,and provide a theoretical basis for the prevention of occupational diseases caused by benzene exposure.

关 键 词：苯 职业暴露 生物标志物 

分 类 号：R135.12[医药卫生—劳动卫生]