肠道菌群对神经退行性疾病影响的研究进展  

Recent advances in effect of gut microbiota on neurodegenerative diseases

作　　者：张大龙[1] 钱智勇[1] ZHANG Da-long;QIAN Zhi-yong(Department of Toxicology,Tianjin Centers for Disease Control and Prevention,Tianjin,3001l,China)

机构地区：[1]天津市疾病预防控制中心毒理科,天津300011

出　　处：《职业与健康》2022年第24期3451-3456,共6页Occupation and Health

基　　金：天津市卫生健康科技青年人才项目(TJWJ2021QN026)。

摘　　要：神经退行性疾病严重影响老年生存质量。其病因尚不明确且没有有效的治疗手段。研究表明,胃肠道通过肠脑轴与中枢神经系统进行交流,肠道菌群失调往往引发为神经系统症状,说明神经性退行性疾病的发病受到肠道菌群的影响。我们通过肠道菌群对神经退行性疾病的影响的研究进展进行综述,为研究神经性退行性疾病的机制及其有效防治提供新视角。Neurodegenerative diseases seriously affect the life quality of the aged.The mechanism of these diseases is not clearly and there are not effective treatments for them.Studies have shown that the gastrointestinal tract communicates with the central nervous system through the gut-brain axis,and gut dysbiosis manifests in neurological disease,indicating that the mechanism of neurodegenerative diseases is linked to gut microbiota. This paper summarizes the research progress on effect ofgut microbiota on neurodegenerative diseases providing new ideas for the mechanism and treatment of neurodegenerative diseases.

关 键 词：神经性退行性疾病 肠道菌群 肠脑轴 

分 类 号：R181.3[医药卫生—流行病学]