The risk factors of SARS-CoV-2 antibody level differences in healthcare workers post vaccination in Siloam hospitals:A nationwide multicenter study  

作　　者：Allen Widysanto Ignatius Bima Prasetya Tandry Meriyanti Veli Sungono Diane Lukito Setiawan Edy Gunawan Bayu Adiputra Jane Olivia Lorens Theresia Santi Cindy Meidy Leony Pradhana Irawan Yusuf Catherine Gunawan 

机构地区：[1]Siloam Hospitals Lippo Village,Banten,Indonesia [2]Faculty of Medicine,Pelita Harapan University,Banten,Indonesia [3]Siloam Hospitals Surabaya,East Java,Indonesia [4]Clinical Research Department Siloam Hospitals Group,Banten,Indonesia [5]Siloam Hospitals Lippo Cikarang,West Java,Indonesia [6]Mochtar Riady Institute for Nanotechnology,Banten,Indonesia

出　　处：《Infectious Medicine》2022年第4期229-235,共7页感染医学（英文）

基　　金：approved by Mochtar Riady Institute for Nanotechnology(MRIN),Tangerang,Banten Indonesia(Protocol No.2108017-03).

摘　　要：Background:Several vaccines have been approved against COVID-19,and 5 have been used in Indonesia.Due to the decrease in antibody levels 3 to 6 months after the second dose of CoronaVac,healthcare workers received the third booster of mRNA vaccine(mRNA-1273)to increase the antibody level.This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers.Methods:This study is a retrospective cohort study of 576 healthcare workers without previous SARS-CoV-2 infection who received 2 doses of CoronaVac and the third dose of mRNA-12736 months after the second dose.Blood samples were obtained 2nd,6th,12th,and 24th weeks after the second dose of CoronaVac vaccine administration,with mRNA-1273 booster on week 20.Quantitative measurements of IgG antibodies were performed with Elecsys Anti-SARS-CoV-2 S immunoassay.We identify the baseline factors predicting post-vaccination antibody titers using univariate and multivariate linear regression analysis.Results:This study comprised 576 participants aged 32 years old,72.05%female,and 45.84%from high-risk occupation subgroups.The median antibodies titer level on the 2nd,6th,12th,and 24th weeks after the second vaccine dose administration were 40.99 u/mL,42.01 u/mL,54.78 u/mL,and 23,225 u/mL.Antibody levels trended highest in female and younger age group(20-29 years old).Conclusions:The third dose of vaccine increased the quantitative SARS-CoV-2 spike IgG antibody titers and eliminated differences in antibodies titer by gender.

关 键 词：Antibodies titer COVID-19 Immune response S-RBD IgG Vaccine 

分 类 号：R186[医药卫生—流行病学]