金振口服液对流感病毒H1N1/FM1株和副流感病毒感染致小鼠肺炎的药理作用  

Pharmacological effects of Jinzhen oral liquid against viral pneumonia in mice infected with influenza H1N1/FM1 and parainfluenza virus

作　　者：张敬升 高双荣[1] 庞博 包蕾[1] 孙静[1] 陈梦苹 徐英莉 曹姗 郭姗姗[1] 赵荣华[1] 崔晓兰[1] ZHANG Jingsheng;GAO Shuangrong;PANG Bo;BAO Lei;SUN Jing;CHEN Mengping;XU Yingli;CAO Shan;GUO Shanshan;ZHAO Ronghua;CUI Xiaolan(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国药物警戒》2023年第1期46-51,95,共7页Chinese Journal of Pharmacovigilance

基　　金：国家重点研发计划(2021YFC1712903);中国中医科学院科技创新工程(C12021A04606)。

摘　　要：目的考察金振口服液对流感病毒H1N1/FM1和副流感病毒感染所致的小鼠肺炎药理作用,为金振口服液的临床应用提供一定的参考。方法采用流感病毒H1N1/FM1和副流感病毒滴鼻感染小鼠造模,考察金振口服液高、中、低剂量组(生药8、4、2 g·kg^(-1)·d^(-1))对小鼠的肺指数、肺组织病理变化和死亡保护作用,并设西药磷酸奥司他韦颗粒、利巴韦林颗粒和中成药小儿热速清口服液作为阳性对照药。结果金振口服液3个剂量组均可不同程度的降低小鼠肺指数、减轻肺组织病理损伤,并对小鼠具有死亡保护作用。结论金振口服液对流感病毒H1N1/FM1和副流感病毒感染所致的肺炎小鼠具有治疗作用。Objective To evaluate the effect of Jinzhen oral liquid(JOL)on a mouse model of pneumonia induced by influenza(H1N1)FM1 strain and parainfluenza virus in order to provide reference for clinical applications.Methods Mice were randomly divided into the normal group,model group,JOL high-dose group(8 g·kg^(-1)·d^(-1)),JOL medium-dose group(4 g·kg^(-1)·d^(-1)),and JOL low-dose group(2 g·kg^(-1)·d^(-1)).Mice were infected via intranasal infection with influenza H1N1/FM1 or parainfluenza virus.Oseltamivir phosphate granules,ribavirin granules and Resuqing oral liquid were used as positive control drugs.Four days after the infection,the lung indexes,inhibition rate,pathological changes were observed.In the death protection experiment,the death rate within 14 days was analyzed.Results Compared with the model group,treatment with JOL could lower the lung indexes,alleviate pathological changes of the lung,and reduce mortality of mice.Conclusion JOL can effectively protect the mouse model from pneumonia induced by influenza H1N1/FM1 or parainfluenza virus.

关 键 词：金振口服液 流感病毒H1N1/FM1 副流感病毒 肺指数 肺组织 磷酸奥司他韦颗粒 利巴韦林颗粒 小儿热速清口服液 

分 类 号：R978.7[医药卫生—药品] R994.11[医药卫生—药学]