基于临床风险信号的含何首乌中药免疫毒性研究进展  

Immunotoxicity of traditional Chinese medicine containing Polygoni Multiflori Radix based on clinical signals

作　　者：雷超 王志飞[1] 谢雁鸣[1] LEI Chao;WANG Zhifei;XIE Yanming(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医临床基础医学所,北京100700

出　　处：《中国药物警戒》2022年第12期1384-1387,共4页Chinese Journal of Pharmacovigilance

基　　金：国家重点研发计划(2018YFC1707400)。

摘　　要：临床上,中药何首乌及其制剂导致的肝损伤类型主要为免疫特异质肝损伤,目前此类型肝损伤的临床风险信号挖掘主要集中在特异性体质及基础疾病、基因标志物、免疫组库、血清代谢物等方面,免疫特异性肝损伤发病隐匿、不易识别,本次研究从免疫毒性角度出发,对含何首乌中药免疫毒性进行初步探讨和挖掘,为下一步的临床试验找准切入点和研究方向,为深入挖掘临床风险信号并构建何首乌肝损伤预警模型提供了科学参考。Clinically,most of the liver injuries caused by Polygonum multiflorum Thunb.and its preparations are immune specific liver injuries.The clinical risk signal mining of this type of liver injury focuses on specific constitution,basic diseases,gene markers,immune group libraries and serum metabolites.The onset of immune specific liver injuries is hidden and difficult to identify.This tentative exploration and mining of the immunotoxicity of Chinese herbal medicine containing Polygonum multiflorum Thunb.is expected to help clarify the priorities of subsequent clinical trials and provide reference for mining of clinical risk signals and the establishment of an early warning model of liver injury caused by Polygonum multiflorum Thunb..

关 键 词：何首乌 免疫特异质 肝损伤 临床风险信号 免疫毒性 

分 类 号：R961[医药卫生—药理学] R994[医药卫生—药学]