静脉注射盐酸利多卡因用于减轻小儿全麻手术丙泊酚注射痛的研究  

Effect of Intravenous Lidocaine Hydrochloride on Relieving Pain of Propofol Injection in Children Under General Anesthesia

作　　者：李卉 曾敏 朱小芳 李露 LI Hui;ZENG Min;ZHU Xiaofang;LI Lu(Xinyu Hospital of Traditional Chinese Medicine,Xinyu Jiangxi 338025,China;Xinyu Mining Hospital,Xinyu Jiangxi 338025,China)

机构地区：[1]新余市中医院,江西新余338025 [2]新余矿业医院,江西新余338025

出　　处：《药品评价》2022年第22期1381-1383,共3页Drug Evaluation

基　　金：新余市社会发展指导性计划项目(20213090895)。

摘　　要：目的:分析静脉注射盐酸利多卡因对于减轻小儿全麻手术丙泊酚注射痛的效果。方法:选取2021年1月至2022年6月新余市中医院收治的全麻手术患儿80例,按照随机数字表法分组。观察组(40例)方案:静脉注射盐酸利多卡因30 s后,静脉注射丙泊酚。对照组(40例)方案:静脉注射相同容积的生理盐水30 s后,静脉注射丙泊酚。观察记录盐酸利多卡因注射前(T0)、注射盐酸利多卡因或生理盐水30 s时(T1)、静脉注射丙泊酚诱导后1 min(T2)时心率(HR)值;术中丙泊酚注射痛发生率;T0、T1、T2、麻醉清醒时简明-麦吉尔疼痛问卷(SF-MPQ)评分;麻醉相关不良反应发生率。结果:对照组T1、T2时的HR值,相比T0时明显降低(P<0.05);观察组T1、T2时的HR值,均高于对照组(P<0.05)。观察组T1、T2、麻醉清醒时的SF-MPQ量表评分,相比对照组均更低(P<0.05);观察组的术中丙泊酚注射痛发生率、麻醉相关不良反应发生率,相比对照组均更低(P<0.05)。结论:静脉注射盐酸利多卡因对于减轻小儿全麻手术丙泊酚注射痛的效果显著。Objective:To analyze the effect of intravenous lidocaine hydrochloride on reducing the pain of propofol injection in children undergoing general anesthesia.Methods:A total of 80 children undergoing general anesthesia surgery in Xinyu Hospital of Traditional Chinese Medicine from January 2021 to June 2022 were selected and grouped according to the random number table method.Observation group(40 cases)program:intravenous injection of lidocaine for 30s,then intravenous injection of propofol.Control group(40 cases)program:intravenous injection of the same volume of normal saline for 30s,and injection of propofol.Observe and record the heart rate(HR)value before lidocaine hydrochloride injection(T0),30s preinjection of lidocaine hydrochloride or normal saline(T1),and 1 min after intravenous propofol induction(T2).Incidence rate,T0,T1,T2,Brief-McGill Pain Questionnaire(SF-MPQ)score when awake from anesthesia,and incidence of anesthesiarelated adverse reactions.Results:The HR values at T1 and T2 in the control group were significantly lower than those at T0(P<0.05);the HR values at T1 and T2 in the observation group were higher than those in the control group(P<0.05).Compared with the control group,the T1,T2,and SF-MPQ scores of the observation group were lower than those of the control group(P<0.05).The incidence of intraoperative propofol injection pain and the incidence of anesthesia-related adverse reactions in the observation group were lower than those in the control group(P<0.05).Conclusion:Intravenous lidocaine hydrochloride has a significant effect on reducing the pain of propofol injection in children undergoing general anesthesia.

关 键 词：利多卡因 麻醉前用药 儿童 学龄前 丙泊酚 注射痛 血流动力学 

分 类 号：R726.1[医药卫生—儿科]