利奈唑胺致视神经炎的文献分析  

Literature Case Analysis of Linezolid-Induced Optic Neuritis

作　　者：武丹威[1] 李锦[1] 李静[1] 刘静雅 滕丽娟 甄健存[1] WU Danwei;LI Jin;LI Jing;LIU Jingya;TENG Lijuan;ZHEN Jiancun(Department of Pharmacy,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Pharmacy,the First Hospital of Zhangjiakou City,Hebei Province,Zhangjiakou 075000,China;Pharmacy Intravenous Admixture Service,People's Hospital of Weifang City,Shandong Province,Weifang 261041,China)

机构地区：[1]北京积水潭医院药学部,北京100035 [2]河北省张家口市第一医院药剂科,张家口075000 [3]山东省潍坊市人民医院静脉药物调配处,潍坊261041

出　　处：《医药导报》2023年第2期262-267,共6页Herald of Medicine

摘　　要：目的了解利奈唑胺致视神经炎的临床特点。方法检索PubMed、Elsevier Science Direct、Embase、Springer-link、Wiley Online Library、Scopus、CNKI、万方数据库,查阅文献报道利奈唑胺致视神经炎的临床特点。结果共检索应用利奈唑胺致视神经炎患者36例,男16例,女19例,1例未提及性别,年龄范围6~81岁,用药原因包括结核、骨与关节感染等。用药剂量方面,1例患者用量为1.6 g·d^(-1),其余患者均未超说明书推荐剂量。患者用药后出现视神经炎的时间为10~1125 d,中位数时间为210 d,利奈唑胺累计剂量为16.8~894 g,中位数剂量为162 g。临床表现为不同程度的视力下降。患者均停药治疗,视力恢复时间7 d~9个月,中位数时间为3个月。转归方面:2例患者视力未改善,其余患者均视力恢复。结论利奈唑胺可引起视神经炎,用药疗程可能是相关危险因素。临床上应注意这一不良反应,保证患者用药安全。Objective To investigate the clinical characteristics of linezolid-induce optic neuritis.Methods PubMed,Elsevier Science Direct,Embase,Springer-Link,Wiley Online Library,Scopus,CNKI,and Wanfang databases were searched,and the clinical features of linezolidine-induced optic neuritis reported in journals were collected.Results A total of 36 patients with linezolid-induce optic neuritis were collected,including 16 male and 19 female patients,and one patient with unclosed gender,with an age range of 6-81 years old.The reasons for the nedication induced tuberculosis,bone,and joint infections.Regarding drug dose,the highest dose in one patient was 1.6 g·d^(-1),and other patients did not exceed the recommended dose on the label.The duration of optic neuritis in patients ranged from ten days to 1125 days,with a median of 210 days,and the cumulative linezolid dose ranged from 16.8 g to 894 g,with a median of 162 g.The clinical manifestations showed different degrees of visual impairment,and all patients were discontinued from the drug treatment.The recovery time of visual acuity was seven days to nine months,with a median time of three months.Visual acuity did not improve in two patients,and visual acuity recovered in the rest of the patients.Conclusion Linezolid can cause optic neuritis,and the duration of medication may be a related risk factor.Clinical attention should be paid to this adverse reaction to ensure the safety of drug use.

关 键 词：利奈唑胺 视神经炎 药品不良反应 

分 类 号：R978[医药卫生—药品] R777[医药卫生—药学]