清痈饮对肛周脓肿术后创面愈合及CCL2因子表达的影响  

Effect of Qingyong decoction on wound healing and the expression of CCL2 after perianal abscess surgery

作　　者：单苏圆[1] 周露 赵诚[1] SHAN Suyuan;ZHOU Lu;ZHAO Cheng(The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,Fujian,China;Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China)

机构地区：[1]福建中医药大学附属人民医院,福建福州350004 [2]福建中医药大学,福建福州350122

出　　处：《湖南中医杂志》2022年第11期15-18,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：福建中医药大学基地课题(JDZX201939)。

摘　　要：目的:观察清痈饮对肛周脓肿热毒炽盛证术后创面愈合及肉芽组织趋化因子配体2(CCL2)因子表达量的影响。方法:将60例肛周脓肿热毒炽盛证患者随机分为治疗组和对照组,每组各30例。2组均采用脓肿切开术,术后对照组采用西医常规治疗,治疗组在对照组基础上加用清痈饮治疗。比较2组创面疼痛评分、创面分泌物评分、创面愈合时间、创面愈合率及CCL2因子表达量。结果:治疗组术后第5、8天创面疼痛评分及创面分泌物评分均低于对照组(P<0.01)。治疗组创面愈合平均时间短于对照组(P<0.01)。治疗组术后第14、21、28天创面愈合率均高于对照组(P<0.01)。治疗组术后第7、14天CCL2因子表达量低于对照组(P<0.01)。结论:清痈饮可通过下调CCL2因子的表达来缓解肛周脓肿热毒炽盛证术后的创面疼痛,减少创面分泌物,促进创面愈合,缩短创面愈合时间。Objective:To investigate the effect of Qingyong decoction on wound healing and the expression level of C-C motif chemokine ligand 2(CCL2)in granulation tissue after surgery for perianal abscess with excessive heat toxin.Methods:A total of 60 patients with perianal abscess with excessive heat toxin were randomly divided into treatment group and control group,with 30 patients in each group.Both groups underwent incision of abscess;the patients in the control group were given conventional Western medicine treatment,and those in the treatment group were given Qingyong decoction in addition to the treatment in the control group.The two groups were compared in terms of wound pain score,wound secretion score,wound healing time,wound healing rate,and the expression level of CCL2.Results:On days 5 and 8 after surgery,the treatment group had significantly lower in wound pain score and wound secretion score than the control group(P<0.01).The treatment group had a significantly shorter average wound healing time than the control group(P<0.01).The treatment group had a significantly higher wound healing rate than the control group on days 14,21,and 28 after surgery(P<0.01).On days 7 and 14 after surgery,the treatment group had a significantly lower expression level of CCL2 than the control group(P<0.01).Conclusion:By downregulating the expression of CCL2,Qingyong decoction can alleviate wound pain,reduce wound secretions,promote wound healing,and shorten wound healing time after surgery for perianal abscess with excessive heat toxin.

关 键 词：肛周脓肿 术后 清痈饮 CCL2 创面疼痛 创面愈合 

分 类 号：R269.571.5[医药卫生—中西医结合]