柴胡加龙骨牡蛎汤的应用规律分析  

Application rule of Chaihu Longgu Muli decoction

作　　者：徐海玉 司国民[2] XU Haiyu;SI Guomin(Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,Shandong,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东大学附属省立医院,山东济南250021

出　　处：《湖南中医杂志》2022年第11期39-46,共8页Hunan Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局齐鲁伤寒流派传承工作室建设项目(LPGZS2012-34);山东省名老中医药专家司国民传承工作室建设项目[鲁卫函(2019)92号]。

摘　　要：目的:探析柴胡加龙骨牡蛎汤的应用规律。方法:依托中医传承辅助平台,录入所收集的医案,建立数据库,利用频次统计、关键词分析、黄金分割法、关联规则法及聚类分析法分析本方证的发病规律、症状规律、用药规律及药-症关系、症状间关联度。结果:柴胡加龙骨牡蛎汤证的核心症状为失眠、烦躁、胸满、心悸、大便干、口苦、口干、纳差等,常见舌质为红舌、淡舌,常见苔质为薄苔、腻苔,常见脉象为弦、细、沉、滑。本方证涉及的中医疾病以心系疾病为主,西医疾病以神经系统疾病和心血管系统疾病为主。临床上使用此方,加味药物多属寒、温性,五味以甘、苦、辛为主,主入脾、肝、心经。结论:柴胡加龙骨牡蛎汤证病位主在肝胆,主症为胸胁胀满、烦惊谵语、一身尽重不可转侧;该方有枢转少阳、镇静安神之功,作用于半表半里及三焦,主治疾病以抑郁、癫狂等情志疾病为主。运用数据分析挖掘本方的临床应用规律,可为正确应用经方提供理论参考。Objective:To investigate the application rule of Chaihu Longgu Muli decoction.Methods:Related medical records were collected and entered into Traditional Chinese Medicine Inheritance Support System to establish a database,and frequency statistics,keyword analysis,golden section method,association rule,and cluster analysis were used to analyze the pathogenesis of the syndrome treated by this prescription,the rule of symptoms,medication rule,drug-symptom association,and the degree of association between symptoms.Results:The core symptoms of the syndrome treated by Chaihu Longgu Muli decoction included insomnia,dysphoria,chest fullness,palpitation,dry stool,bitter taste,dry mouth,and poor appetite;the common natures of the tongue included red tongue and pale tongue,and the common natures of coating on the tongue included thin coating and glossy coating;common pulse manifestations included wiry pulse,thready pulse,deep pulse,and slippery pulse.The syndrome treated by this prescription mainly involved heart diseases in traditional Chinese medicine and nervous system diseases and cardiovascular system diseases in Western medicine.In the clinical application of this prescription,the drugs added were mostly cold or warm in nature and had a sweet,bitter,or pungent taste,and most of them entered the spleen,liver,and heart meridians.Conclusion:Liver and gallbladder are the main disease locations of the syndrome treated by Chaihu Longgu Muli decoction,and the main symptoms include chest fullness,delirious speech,and being unable to turn around.This prescription has the functions of Shaoyang pivoting and sedation and tranquillization and acts on half-superficies and half-interior and triple energizers for the treatment of emotional diseases such as depression and mania.An analysis of the clinical application rule of this prescription based on data mining can provide a theoretical basis for the correct application of classical prescriptions.

关 键 词：柴胡加龙骨牡蛎汤 药症关系 方证研究 应用规律 

分 类 号：R289.5[医药卫生—方剂学]