抗凝药师参与住院患者华法林用药管理的效果  

Effect of Anticoagulant Pharmacists Participating in the Management of Warfarin Medication in Hospitalized Patients

作　　者：张一[1] 陈楠[1] 华之卉[1] 刘相端[1] 刘秀梅[1] ZHANG Yi;CHEN Nan;HUA Zhihui;LIU Xiangduan;LIU Xiumei(Department of Pharmacy,Zhengzhou People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院药学部,河南郑州450000

出　　处：《河南医学研究》2023年第2期231-234,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191090);河南省医学科技攻关计划(联合共建)项目(2018020846)。

摘　　要：目的探讨临床抗凝药师参与住院患者华法林用药管理的效果。方法选取2020年7月至2021年6月在郑州人民医院接受华法林治疗的200例住院患者作为研究对象,其中2020年7―12月住院患者为对照组(100例),2021年1―6月住院患者为观察组(100例),在服用华法林期间,对照组患者未接受临床药师的管理和监测,观察组患者接受临床抗凝药师的管理和监测。对两组患者用药有效性、安全性、合理性以及满意度进行评价。结果观察组患者华法林首次达到治疗范围的时间短于对照组,国际标准化比值(INR)达标率高于对照组,治疗期间血栓发生率低于对照组(P<0.05);观察组患者服用华法林期间,各种出血事件的发生率(3.00%)低于对照组(12.00%)(P<0.05);观察组患者服用华法林期间,剂量调整不规范、联合用药不合理和停药时机不当等用药不合理情况发生率(分别为2.00%、3.00%和1.00%)均低于对照组(分别为9.00%、11.00%和8.00%)(P<0.05);观察组患者出院前用药满意度评分[(2.91±0.35)分]高于对照组[(2.57±0.71)分](P<0.05)。结论临床抗凝药师干预后,能有效改善住院患者华法林用药的有效性和安全性,避免各种不合理现象的发生,提高抗凝用药治疗的满意度。Objective To explore the effect of clinical anticoagulant pharmacists participating in the management of warfarin medication in hospitalized patients.Methods A total of 200 hospitalized patients who received warfarin treatment in Zhengzhou People’s Hospital from July 2020 to June 2021 were selected as the research subjects.The hospitalized patients from July to December 2020 were the control group(100 cases),and the hospitalized patients from January to June 2021 were the observation group(100 cases).During the period of taking warfarin,the patients in the control group did not receive the management and monitoring of the clinical pharmacist,and the patients in the observation group were received the management and monitoring of the clinical anticoagulant pharmacist.The efficacy,safety,rationality and satisfaction of the two groups of patients were evaluated.Results The time of warfarin reaching the therapeutic range for the first time in the observation group was shorter than that in the control group,the international normalized ratio(INR)reaching rate was higher than that in the control group,and the incidence of thrombosis during the treatment was lower than that in the control group(P<0.05).During the period of taking warfarin,the incidence of various bleeding events in the observation group(3.00%)was lower than that in the control group(12.00%)(P<0.05),and the incidence of irregular dose adjustment,unreasonable combination drug use and improper drug withdrawal timing in the observation group(2.00%,3.00%and 1.00%,respectively)were lower than those in the control group(9.00%,11.00%and 8.00%,respectively)(P<0.05).The score of medication satisfaction in the observation group before discharge[(2.91±0.35)points]was higher than that in the control group[(2.57±0.71)points](P<0.05).Conclusion After clinical anticoagulant pharmacist intervention,it could effectively improve the effectiveness and safety of warfarin medication in hospitalized patients,avoid the occurrence of various unreasonable phenomena,and impro

关 键 词：临床药师 华法林 住院患者 抗凝管理 

分 类 号：R969.3[医药卫生—药理学]