子痫前期患者血清白细胞介素-12、基质细胞衍生因子-1的表达及其与不良妊娠结局的相关性  

Expression of Serum Interleukin-12 and Stromal Cell Derived-Factor 1 in Patients with Preeclampsia and Their Correlation with Adverse Pregnancy Outcomes

作　　者：张冉[1] 王菊 白玉芳[1] ZHANG Ran;WANG Ju;BAI Yufang(Department of Obstetrics,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院产科,河南南阳473000

出　　处：《河南医学研究》2023年第2期299-302,共4页Henan Medical Research

摘　　要：目的观察子痫前期患者血清白细胞介素-12(IL-12)、基质细胞衍生因子-1(SDF-1)的表达,并分析二者与不良妊娠结局的相关性。方法前瞻性纳入2019年6月至2021年6月南阳市中心医院收治的96例子痫前期患者作为研究对象,所有患者均随访至分娩结束后30 d,根据本次妊娠最终是否发生不良妊娠结局分组,全部患者于入院时检测血清IL-12、SDF-1水平,以点二列分析子痫前期患者血清IL-12、SDF-1水平与不良妊娠结局的相关性。结果96例子痫前期患者中无失访病例,随访至产后30 d,其中发生不良妊娠结局患者25例,占比为26.04%;发生组子痫前期患者血清IL-12、SDF-1水平高于未发生组,差异有统计学意义(P<0.05);经点二列相关性检验,结果显示,子痫前期患者血清IL-12、SDF-1水平与不良妊娠结局呈正相关(r=0.640、0.656,P<0.001);经logistic回归分析,结果显示,高血清IL-12水平、高SDF-1水平是不良妊娠结局的风险因子(OR>1,P<0.05)。结论子痫前期患者血清IL-12、SDF-1水平可能与不良妊娠结局存在一定关系,且高血清IL-12、高SDF-1水平子痫前期患者不良妊娠结局发生风险较高。Objective To observe the expression levels of serum interleukin-12(IL-12)and stromal cell derived-factor 1(SDF-1)in patients with preeclampsia,and to analyze the correlation between them and adverse pregnancy outcomes.Methods A total of 96 patients with preeclampsia treated in Nanyang Central Hospital from June 2019 to June 2021 were prospectively included as the research objects.All patients were followed up to 30 days after delivery.According to whether there was adverse pregnancy outcome at the end of this pregnancy,all patients were divided into groups.The levels of serum IL-12 and SDF-1 were detected at admission,and the correlation between serum IL-12 and SDF-1 in preeclampsia patients and adverse pregnancy outcome was analyzed by point and column.Results There were no lost follow-up cases in 96 patients with preeclampsia.They were followed up to 30 days after delivery,including 25 patients with adverse pregnancy outcomes,accounting for 26.04%.The levels of serum IL-12 and SDF-1 in preeclampsia patients in the occurrence group were higher than those in preeclampsia patients in the non occurrence group,and the difference was statistically significant(P<0.05).The point and column results showed that the levels of serum IL-12 and SDF-1 in preeclampsia patients were positively correlated with adverse pregnancy outcomes(r=0.640,0.656,P<0.001).Logistic regression analysis showed that high serum levels of IL-12 and SDF-1 were risk factors for adverse pregnancy outcomes(OR>1,P<0.05).Conclusion The levels of serum IL-12 and SDF-1 in patients with preeclampsia may be related to adverse pregnancy outcomes,and high serum IL-12 and SDF-1 levels have a higher risk of adverse pregnancy outcomes.

关 键 词：子痫前期 白细胞介素-12 基质细胞衍生因子-1 胎盘早剥 胎儿窘迫 

分 类 号：R714.24[医药卫生—妇产科学]