黏膜免疫佐剂研究进展  

Research Progress of Mucosal Immune Adjuvant

作　　者：张一帜 张媛[1] 李建[1] 王秀丽[1] 刘元杰 辛凌翔[1] 任小侠[1] 彭国瑞[1] 宋佳诚 李俊平[1] ZHANG Yizhi;ZHANG Yuan;LI Jian;WANG Xiuli;LIU Yuanjie;XIN Lingxiang;REN Xiaoxia;PENG Guorui;SONG Jiacheng;LI Junping(China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《中国动物传染病学报》2022年第6期181-188,共8页Chinese Journal of Animal Infectious Diseases

摘　　要：佐剂对于疫苗免疫所产生的免疫反应有着非常重要的作用。出于各种原因,只有一小部分的佐剂获得了卫生部门的批准,而目前通过批准的佐剂经黏膜免疫途径免疫后还不能激发强有力的免疫反应。因而国内外对于黏膜免疫佐剂的需求十分迫切,近二十年来,针对黏膜免疫佐剂的研究从作为抗原载体到激发特定免疫反应都有新的突破。然而,这些佐剂的安全性和有效性始终是最主要的问题,需要更多的研究证实。本文整理汇总了目前黏膜免疫佐剂的发展并讨论了部分佐剂发挥其功能的内在原因。Adjuvants play a critical role in the immune response produced by vaccination. For various reasons, only a few number of adjuvants have been approved by the health authorities, and currently the approved adjuvants have not been able to elicit a strong enhancement in mucosal immune system. Therefore, the demand for mucosal immune adjuvants is very urgent all over the world. In the past two decades, research on mucosal immune adjuvants has made several breakthroughs from the use as antigen delivery system to the stimulating specifi c immunity. However, the safety and effectiveness of these adjuvants have always been the main issues and more research is needed for improvement. This article summarized the current development of mucosal immune adjuvants and discussed their effects on the enhancement of the immunity.

关 键 词：黏膜免疫 佐剂 抗原载体 TOLL样受体 细胞因子 

分 类 号：S852.4[农业科学—基础兽医学]