Reviving the use of inhibitors of matrix metalloproteases in spinal cord injury:a case for specificity  

作　　者：Zubair Ahmed 

机构地区：[1]Neuroscience and Ophthalmology,Institute of Inflammation and Ageing,University of Birmingham,Edgbaston,Birmingham,UK [2]Center for Trauma Sciences Research,University of Bimringham,Edgbaston,Birmingham,UK

出　　处：《Neural Regeneration Research》2023年第9期1925-1930,共6页中国神经再生研究（英文版）

摘　　要：At present,there are no resto rative therapies in the clinic for spinal cord injury,with current treatments offering only palliative treatment options.The role of matrix metalloproteases is well established in spinal cord injury,howeve r,translation into the clinical space was plagued by early designs of matrix metalloprotease inhibitors that lacked specificity and fears of musculos keletal syndrome prevented their further development.Newe r,much more specific matrix metalloprotease inhibitors have revived the possibility of using these inhibitors in the clinic since they are much more specific to their to rget matrix metalloproteases.Here,the evidence for use of matrix metalloproteases after spinal cord injury is reviewed and researche rs are urged to overcome their old fears rega rding matrix metalloprotease inhibition and possible side effects for the field to progress.Recently published work by us shows that inhibition of specific matrix metalloproteases after spinal cord injury holds promise since four key consequences of spinal cord injury could be alleviated by specific,next-gene ration matrix metalloprotease inhibitors.For example,specific inhibition of matrix metalloprotease-9 and matrix metalloprotease-12 within 24 hours after injury and for 3 days,alleviates spinal cord injury-induced edema,blood-s pinal co rd barrier breakdown,neuro pathic pain and resto res sensory and locomotor function.Attempts are now underway to translate this therapy into the clinic.

关 键 词：axon regeneration blood-spinal cord barrier EDEMA functional recovery matrix metalloprotease-9 matrix metalloproteses-12 PAIN spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]