棘球绦虫诱导肝纤维化机制研究进展  

Mechanism of hepatic fibrosis associated with Echinococcus:a review

作　　者：张仁杰 庞华胜 李景中[3] 罗钊辉 艾琳 宋鹏 蔡玉春 卢艳 莫筱瑾 陈木新 陈家旭[1,4] ZHANG Ren-jie;PANG Hua-sheng;LI Jing-zhong;LUO Zhao-hui;AI Lin;SONG Peng;CAI Yu-chun;LU Yan;MOXiao-jin;CHEN Mu-xin;CHEN Jia-xu(National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),National Health Commission Key Laboratory of Parasite and Vector Biology,WHO Collaborating Centre for Tropical Diseases,National Center for International Research on Tropical Diseases,Shanghai 200025,China;Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention,China;Tibet Autonomous Region Center for Disease Control and Prevention,National Health Commission Key Laboratory of Echinococcosis Prevention and Control,China;Hainan Tropical Diseases Research Center(Hainan Sub-Center,Chinese Center for Tropical Diseases Research),Haikou,Hainan 571199,China;Shenzhen Center for Disease Control and Prevention,Shenzhen,Guangdong 518073,China)

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、WHO热带病合作中心、国家级热带病国际联合研究中心,上海200025 [2]新疆维吾尔自治区疾病预防控制中心 [3]西藏自治区疾病预防控制中心、国家卫生健康委员会包虫病防治研究重点实验室 [4]海南热带病研究中心(国家热带病研究中心海南分中心),海南海口571199 [5]广东省深圳市疾病预防控制中心,广东深圳518073

出　　处：《中国血吸虫病防治杂志》2022年第6期646-653,共8页Chinese Journal of Schistosomiasis Control

基　　金：国家重点研发计划(2021YFC2300800,2021YFC2300801);国家卫生健康委员会包虫病防治研究重点实验室项目(2020WZK2002,2021WZK1003);中山大学热带病防治研究教育部重点实验室开放基金(2019kfkt02);中国医学科学院中央级公益性科研院所基本科研业务费专项资金(2019PT320004);广东省深圳市科技创新委员会面上项目(JCYJ20210324135207021)。

摘　　要：棘球蚴病是一种由棘球蚴感染引起的人兽共患寄生虫病,可导致以肝脏为主的多种重要器官纤维化,而肝纤维化可进一步发展为肝硬化。早期肝纤维化可逆,研究棘球绦虫诱发肝纤维化的机制对于早期肝纤维化预防和治疗具有重要意义。近年来有关棘球绦虫诱发肝纤维化的研究主要集中在细胞因子和免疫细胞等方面。本文就棘球绦虫感染人体或小鼠后宿主免疫细胞及相关因子参与调控肝纤维化进展的作用机制研究进展进行综述。Echinococcosis is a zoonotic parasitic disease caused by Echinococcus infections,and this disorder may cause fibrosis of multiple vital organs,which may further progress into cirrhosis.Early-stage hepatic fibrosis is reversible,and unraveling the mechanisms underlying hepatic fibrosis induced by Echinococcus infections is of great significance for the prevention and treatment of early-stage hepatic fibrosis.Recently,the studies pertaining to hepatic fibrosis associated with Echinococcus infections focus on cytokines and immune cells.This review summarizes the advances in the mechanisms underlying host immune cells-and cytokines-mediated hepatic fibrosis in humans or mice following Echinococcus infections.

关 键 词：棘球蚴病 棘球绦虫 肝纤维化 免疫细胞 细胞因子 

分 类 号：R532.32[医药卫生—内科学]