催产素及其相关受体参与镇痛作用的研究进展  

Advance in the Study of Oxytocin and Its Related Receptors Involved in Analgesia

作　　者：尹静雯 樊龙昌[1] Yin Jingwen;Fan Longchang(Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科,武汉430030

出　　处：《华中科技大学学报（医学版）》2022年第6期870-873,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省自然科学基金面上项目(No.2019CFB445)。

摘　　要：神经激素催产素(oxytocin,OT)为人熟知的功能不仅包括其促进分娩时子宫收缩、哺乳以及在社会行为中的作用,它也被认为是内源性镇痛的重要介质。催产素及外周/中枢神经系统表达的催产素受体显示出强大的镇痛作用,它们因参与感觉加工和疼痛感知的调节而越来越受到关注。该文总结了近年来催产素及其相关受体在疼痛调控方面研究的最新进展。Being best-known for its function in lactation,uterine contraction during parturition,and for its role in social behaviour,the neurohormone oxytocin(OT)has also been implicated as an important mediator in endogenous analgesia.Oxytocin and oxytocin receptors expressed in the peripheral/central nervous system show their powerful analgesic effects,and they have attracted more and more attention because of their involvement in sensory processing and pain perception.This paper reviews the recent progress in the study of oxytocin and its related receptors in pain modulation.

关 键 词：疼痛 催产素 催产素受体 TRPV1通道 

分 类 号：R614[医药卫生—麻醉学]