基于投影式光固化的高精度生物3D打印策略综述  

High‑precision 3D bioprinting strategy based on projection‑based 3D printing

作　　者：何超凡 贺永[1,2,3] HE Chaofan;HE Yong(School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,China;Cancer Center,Zhejiang University,Hangzhou 310058,China;Key Laboratory of Materials Processing and Mold,Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]浙江大学机械工程学院,浙江杭州310027 [2]浙江大学癌症中心,浙江杭州310058 [3]郑州大学材料加工与模具重点实验室,河南郑州450002

出　　处：《长沙理工大学学报（自然科学版）》2022年第4期1-8,共8页Journal of Changsha University of Science and Technology:Natural Science

基　　金：国家重点研究开发计划(2018YFA0703000);国家自然科学基金资助项目(T2121004、U1909218)。

摘　　要：【目的】探讨投影式光固化3D打印(projection-based 3D printing,PBP)在打印生物材料时影响打印精度的因素,研究高精度生物3D打印策略。【方法】分析生物材料相比于传统聚合物的不同特性。结合PBP技术的特点,从材料体系、打印工艺、曝光参数和设备开发4个方面探讨并总结提高打印精度的方法。【结果】明确了生物材料打印精度不佳的主要因素,总结了可行的高精度生物3D打印策略。【结论】生物3D打印的精度上限取决于光学精度,然而还有诸多因素共同决定了其精度下限,例如曝光参数、打印工艺、材料体系和光学系统畸变等,因此,综合考虑这些因素对实现高精度生物3D打印至关重要。[Purposes]This paper aims to discuss the factors that affect the printing resolution of projection-based 3D printing(PBP)in bio-materials and study the high-precision 3D bioprinting strategy.[Methods]The different properties of biomaterials compared with traditional polymers were analyzed.Based on the characteristics of PBP,the methods to improve the printing resolution are discussed and summarized from four aspects:material system,printing process,exposure parameters and equipment development.[Findings]The main factors of poor printing resolution of biomaterials were identified,and feasible high-precision 3D bioprinting strategies were summarized.[Conclusions]The upper limit of the resolution of bioprinting depends on the optical resolution.However,many factors synergetic determine the lower limit,such as exposure parameters,printing process,material system,optical system distortion,etc.Therefore,it is essential to comprehensively consider these factors to achieve high-precision 3D bioprinting connsider these factors to achieve high-precision 3D bioprinting.

关 键 词：投影式光固化3D打印 高精度 生物3D打印 生物材料 增材制造 

分 类 号：TH161[机械工程—机械制造及自动化]