米非司酮联合米索前列醇在药物流产中的应用效果  

Application Effect of Mifepristone Combined with Misoprostol in Drug Abortion

作　　者：白玉 赵新玲 BAI Yu;ZHAO Xinling(Department of Gynecology,Luoyang Maternal and Child Health Hospital,Luoyang Henan 471000,China)

机构地区：[1]洛阳市妇幼保健院妇科,河南洛阳471000

出　　处：《临床研究》2023年第2期65-68,共4页Clinical Research

摘　　要：目的 分析米非司酮+米索前列醇在药物流产中的使用价值。方法 选入洛阳市妇幼保健院2019年8月至2022年2月收治的120例药物流产孕妇,使用随机数字表法分成两组。对照组60例实行清宫术流产,试验组60例行米非司酮+米索前列醇流产,观察组间完全流产、不完全流产及流产失败率、并发症发生率及不良反应发生情况、阴道出血量/时间和子宫内膜厚度、妊娠物排出时间、生活质量。结果 相比对照组,试验组完全流产率较低,差异有统计学意义(P<0.05),两组不完全流产和流产失败率对比,差异无统计学意义(P>0.05)。相比对照组,试验组并发症发生率比对照组低,差异有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。相比较对照组,试验组阴道出血量、阴道出血时间及子宫内膜厚度更高,差异有统计学意义(P<0.05),两组妊娠物排出时间差异无统计学意义(P>0.05)。治疗后试验组生活质量评分比对照组高,差异有统计学意义(P<0.05)。结论 虽然米非司酮联合米索前列醇完全流产率低,但是其在并发症发生率和保护子宫内膜方面效果更好,并且流产后患者生活质量相对较好。Objective To analyze the applied value of mifepristone and misoprostol in drug abortion. Methods A total of 120 pregnant women with drug abortions admitted to Luoyang Maternal and Child Health Hospital from August 2019 to February 2022 were selected and divided into two groups using the random number table method. 60 patients in the control group received abortion by curettage, and 60 patients in the experimental group received mifepristone and misoprostol abortion.Total abortion, incomplete abortion, abortion failure rate, complication rate and adverse reactions, vaginal bleeding volume/time,endometrial thickness, gestational discharge time, and quality of life were observed between groups. Results Compared with the control group, the complete abortion rate of the experimental group was lower, and the difference was statistically significant(P<0.05), but there was no statistically significant difference in incomplete abortion and abortion failure rate between groups(P>0.05). The complication rate of the experimental group was lower than that of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Compared with the control group, the amount of vaginal bleeding, vaginal bleeding time, and endometrial thickness in experimental groups was higher, and the differences were statistically significant(P<0.05), while the gestational discharge time between the two groups was not statistically significant(P>0.05). After treatment, the life quality score of the experimental group was higher than that of the control group, and the difference was statistically significant(P<0.05).Conclusion Although Mifepristone combined with misoprostol has a low rate of complete abortion, it is better in terms of complication rate and endometrial protection, and the quality of life of patients after abortion is relatively good.

关 键 词：药物流产 米非司酮 米索前列醇 流产成功率 不良反应发生率 

分 类 号：R932[医药卫生—生药学]