烟碱对线粒体调节作用的研究进展  

Research Progress on the Regulatory Effect of Nicotine on Mitochondria

作　　者：田建露 王红娟[1] 陈欢[1] 侯宏卫[1] 胡清源[1] TIAN Jianlu;WANG Hongjuan;CHEN Huan;HOU Hongwei;HU Qingyuan(China National Tobacco Quality Supervision&Test Center,Key Laboratory of Tobacco Biological Effects,Zhengzhou 450001,China)

机构地区：[1]国家烟草质量监督检验中心,烟草生物学效应重点实验室,郑州450001

出　　处：《中国细胞生物学学报》2022年第10期1987-1994,共8页Chinese Journal of Cell Biology

基　　金：省部级重点项目[批准号:110202001031(JY-14)、110202101018(XX-04)]资助的课题。

摘　　要：烟碱是烟草中的主要致瘾性成分,也是一种毒性物质。线粒体作为一种半自主细胞器,在细胞的生长、分化、凋亡、能量供应与信息传递等过程中发挥重要的功能,线粒体相关机制的失调会对细胞乃至机体产生不可逆的损害。已有研究表明,线粒体是烟碱作用的潜在靶点,烟碱可通过依赖或不依赖烟碱型乙酰胆碱受体的方式对线粒体进行调节,且烟碱浓度、烟碱作用时间和作用靶细胞不同时,对线粒体的调节作用也不同。该文聚焦烟碱对线粒体基因表达、动力学、呼吸链、氧化应激及钙稳态和单胺氧化酶活性等的影响,从正向和负向调节作用两方面,综述了烟碱对线粒体的调节作用及其机制,以期为后续研究烟碱对线粒体产生的多重生物学效应的相关机制及防控策略提供思路。Nicotine is the principal addictive component in tobacco,but also a toxic substance.As a semi-autonomous organelle,mitochondria act significant roles in various biological functions,such as the process of cell growth,differentiation,apoptosis,energy supply and signal transduction.Mitochondria dysfunction will cause irreversible damage to cells and even the organism.Previous studies have shown that mitochondria are the potential target of nicotine.Nicotine can regulate mitochondria in a nicotinic acetylcholine receptors dependent or independent way.When the concentration gradient,exposure duration and target cells are different,the effects of nicotine on mitochondria are different.This review focuses on the effects of nicotine on mitochondrial gene expression,mitochondrial dynamics,mitochondrial respiratory chain,oxidative stress,calcium homeostasis and monoamine oxidase activity.The regulatory effects and mechanisms of nicotine on mitochondria are summarized from both positive and negative aspects;and it provides perspectives for the follow-up study of related mechanisms and control strategies of multiple biological effects of nicotine acting on mitochondria.

关 键 词：烟碱 线粒体 动力学 呼吸链 活性氧 

分 类 号：R99[医药卫生—毒理学]