Hybrid multimode - multicore fibre based holographic endoscope for deep-tissue neurophotonics  

作　　者：Yang Du Sergey Turtaev Ivo T Leite Adrian Lorenz Jens Kobelke Katrin Wondraczek Tomas Cizmar 

机构地区：[1]Leibniz Institute of Photonic Technology,Albert-Einstein-Straβe 9,Jena,07745,Germany [2]Institute of Scientific Instruments of CAS,Kralovopolska 147,Brno,61264,Czechia [3]Institute of Applied Optics,Friedrich Schiller University Jena,Frobelstieg 1,07743 Jena,Germany

出　　处：《Light(Advanced Manufacturing)》2022年第3期84-92,共9页光（先进制造）（英文）

基　　金：The authors acknowledge the support from the European Research Council(724530),Ministry of Education,Youth and Sports(CZ.02.1.01/0.0/15_003/0000476);Thüringer Ministerium für Wirtschaft,the European Regional Development Fund(CZ.02.1.01/0.0/15_003/0000476);Wissenschaft und Digitale Gesellschaft,the Federal Ministry of Education and Research,Germany(BMBF);the Thüringer Aufbaubank.

摘　　要：In-vivo microendoscopy in animal models became a groundbreaking technique in neuroscience that rapidly expands our understanding of the brain.Emerging hair-thin endoscopes based on multimode fibres are now opening up the prospect of ultra-minimally invasive neuroimaging of deeply located brain structures.Complementing these advancements with methods of functional imaging and optogenetics,as well as extending its applicability to awake and motile animals constitute the most pressing challenges for this technology.Here we demonstrate a novel fibre design capable of both,high-resolution imaging in immobilised animals and bending-resilient optical addressing of neurons in motile animals.The optimised refractive index profile and the probe structure allowed reaching a spatial resolution of 2μm across a 230μm field of view for the initial layout of the fibre.Simultaneously,the fibre exhibits negligible cross-talk between individual inner-cores during fibre deformation.This work provides a technological solution for imaging-assisted spatially selective photo-activation and activity monitoring in awake and freely moving animal models.

关 键 词：Multimode fibre Multicore fibre Fibre-based imaging MICROENDOSCOPY ENDOMICROSCOPY Holographic endoscopy 

分 类 号：TN253[电子电信—物理电子学]