Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases  

作　　者：Na Kang Xiaohang Liu Kabeer Haneef Wanli Liu 

机构地区：[1]School of Life Sciences,Institute for Immunology,MOE Key Laboratory of Protein Sciences,Beijing Advanced Innovation Center for Structural Biology,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Beijing Key Laboratory for Immunological Research on Chronic Diseases,Tsinghua University,Beijing,China [2]Tsinghua‐Peking Center for Life Sciences,Beijing,China

出　　处：《Rheumatology & Autoimmunity》2022年第4期185-197,共13页风湿病与自身免疫（英文）

基　　金：The authors acknowledge support from the Tsinghua University Spring Breeze Fund,Center for Life Sciences,and Institute for Immunology,Tsinghua University,and grants from the Ministry of Science and Technology of China(2021YFC2300500 and 2021YFC2302403);National Natural Science Foundation of China(32141004,81825010,81730043,and 81621002).

摘　　要：All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli.The immune system activates when damaged or injured cells release damage‐associated molecular patterns(DAMPs).In addition to well‐characterized DAMPs such as high‐mobility group box 1 and adenosine triphosphate,studies on new classes of DAMPs have emerged.Here,we review recent reports of a new class of isoprenoid‐derived DAMPs,including farnesyl pyrophosphate and geranylgeranyl pyrophosphate,both of which are pivotal metabolic inter-mediates of the mevalonate pathway.We also explore the roles of old and new DAMPs in autoimmune diseases that result from dysregulated inflammation.The findings highlight that understanding the functional mechanisms of DAMPs is important to enrich the DAMP family and decipher their immunoregulatory mechanisms to provide new therapeutics for the prevention and treatment of autoimmune diseases.

关 键 词：autoimmune diseases damage‐associated molecular patterns farnesyl pyrophosphate geranylgeranyl diphosphate mevalonate pathway 

分 类 号：O62[理学—有机化学]