cGAS-STING信号通路与脓毒症肠屏障功能障碍相关性的研究进展  

Research progress on the correlation between c GAS-STING signaling pathway and intestinal barrier dysfunction in sepsis

作　　者：高薇薇 王枭 关鹏(综述)[1] 高万朋(审校)[1] GAO Wei-wei;WANG Xiao;GUAN Peng(Department of Emergency,Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China)

机构地区：[1]天津中医药大学第二附属医院急诊科,天津300000

出　　处：《中国临床新医学》2023年第1期102-106,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：天津中医药大学第二附属医院“青苗计划”课题(编号:QMJH202014)。

摘　　要：脓毒症的发病机制复杂。近年来研究证实,脓毒症发生时,cGAS-STING信号通路激活及作用机制对于改善脓毒症肠屏障功能障碍具有重要意义。该文就cGAS-STING信号通路的激活、cGAS-STING信号通路与脓毒症肠道炎症反应及cGAS-STING信号通路对肠屏障功能的影响作一综述。The pathogenesis of sepsis is complex.In recent years,studies have confirmed that the activation and mechanism of cyclic guanosine monophosphate-adenosine monophosphate synthetase(cGAS)-stimulator of interferon genes(STING)(cGAS-STING)signaling pathway are of great significance in improving intestinal barrier dysfunction in sepsis.This paper reviews the activation of cGAS-STING signaling pathway,cGAS-STING signaling pathway and septic intestinal inflammatory reaction and the effect of cGAS-STING signaling pathway on intestinal barrier function.

关 键 词：cGAS-STING信号通路 肠道屏障功能 脓毒症 肠道炎症 

分 类 号：R631[医药卫生—外科学]