2011-2020年神经内科脑梗死住院病例医院感染病原菌及耐药菌分布  

Analysis of pathogenic distribution of bacteria and evolution of drug-resistant strain spectrum in patients with cerebral infarction from 2011 to 2020

作　　者：刘婷 于正浩[1,3] 杜明梅 姚宏武[3] 白艳玲[3] 刘运喜 LIU Ting;YU Zheng-hao;DU Ming-mei;YAO Hong-wu;BAI Yan-ling;LIU yun-xi(Medical School of Chinese PLA,Beijing 100853,China;不详)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第二医学中心保健一科国家老年疾病临床研究中心,北京100853,解放军医学院,北京100853 [3]解放军总医院第一医学中心疾病预防控制科,北京100853

出　　处：《中华医院感染学杂志》2022年第24期3711-3714,共4页Chinese Journal of Nosocomiology

基　　金：军事医学创新工程专项基金资助项目(18CXZ038)。

摘　　要：目的监测10年神经内科脑梗死感染患者检出病原菌情况及主要耐药菌的变迁。方法收集解放军总医院第一医学中心2011年1月1日-2020年12月31日诊断为脑梗死的患者,登记感染患者的基本情况、检出病原菌名称、耐药菌等,使用统计软件分析10年的变迁。结果共从853例1660例次感染患者中检出病原菌3250株,其中革兰阴性菌1868株(57.48%),真菌712株(21.91%),革兰阳性菌670株(20.62%),分析显示10年来革兰阴性菌始终为脑梗死感染患者主要的检出菌,多药耐药鲍氏不动杆菌检出占比最高为33.85%,耐药菌的检出情况10年有明显的变迁。结论神经内科脑梗死患者院内感染以革兰阴性菌为主,检出耐药菌10年的变迁分析可为脑梗死感染的预防和经验性抗菌药物治疗提供参考。OBJECTIVE To analyze the pathogenic bacteria detected in patients with cerebral infarction infection in the department of neurology and the evolution of main drug-resistant bacteria in 10 years.METHODS Patients diagnosed with cerebral infarction in the First Medical Center of PLA General Hospital from Jan 1,2011 to Dec 31,2020 were recruited.The basic information,pathogen names and drug-resistant bacteria of infected patients were registered,and the variation in 10 years were analyzed by statistical software.RESULTS A total of 3250 strains of pathogenic bacteria were detected from 1660 patients with secondary infection in 853 cases,including 1868 strains of gram-negative bacteria(57.48%),712 strains of fungi(21.91%)and 670 strains of gram-positive bacteria(20.62%).The analysis showed that gram-negative bacteria were always the main bacteria detected in patients with cerebral infarction in the past 10 years.The detection rate of multidrug-resistant Acinetobacter baumannii was 33.85%,and the detection situation of drug-resistant bacteria changed significantly in 10 years.CONCLUSION The pathogen of nosocomial infection in cerebral infarction patients admitted in neurology department is mainly gram-negative bacteria.The analysis of the evolution of drug-resistant bacteria spectrum in 10 years can provide reference for the prevention and empirical antibacterial treatment of cerebral infarction infection.

关 键 词：神经内科 脑梗死 医院感染 病原菌 耐药菌 

分 类 号：R378[医药卫生—病原生物学]