各种组学分析在体表慢性难愈合创面中的研究进展  

Research advances of various omics analyses in chronic refractory wounds on body surface

作　　者：曾帅丹 杨磊[1] Zeng Shuaidan;Yang Lei(Department of Burns,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院烧伤科,广州510515

出　　处：《中华烧伤与创面修复杂志》2023年第1期75-80,共6页Chinese Journal of Burns And Wounds

基　　金：广东省重点领域研发计划项目(2020B1111150001);广东省自然科学基金项目(2020A151501108);广东省省级科技计划项目(2018KJYZ005);深圳市医疗卫生三名工程项目(SZSM202011012)。

摘　　要：体表慢性难愈合创面的诊断和治疗一直充满着挑战,对医疗和社会造成巨大负担。利用高通量测序技术结合组学分析可以揭示慢性创面形成的潜在机制,识别与慢性创面诊断、预后和筛查相关的潜在生物标志物。而联合多个水平的组学分析能进一步探索和理解其中详细的分子机制,为制订个性化治疗方法提供线索,为慢性创面的精准医疗打下坚实的基础。因此,该文针对近年各种组学分析在体表慢性难愈合创面相关研究中的进展进行综述。The diagnosis and treatment of chronic refractory wounds on body surface has always been full of challenges,and it also poses a huge burden on medical care and society.High-throughput sequencing combined with omics analysis can reveal potential mechanisms of chronic wound formation,and identify potential biomarkers related to diagnosis,prognosis,and screening of chronic wound.Combined with multiple levels of omics analysis,the detailed molecular mechanism of chronic wound development can be further explored and understood,so as to provide clues for the formulation of personalized treatment methods and lay a solid foundation for the precision medicine of chronic wounds.Therefore,this review addresses the recent progress of various omics analyses in chronic refractory wounds on body surface.

关 键 词：精准医学 蛋白质组学 慢性创面 创面修复 

分 类 号：R632.1[医药卫生—外科学] R34[医药卫生—临床医学]