Self-organization principles in stem-cell-derived synthetic embryo models  

作　　者：Min Bao 

机构地区：[1]California Institute of Technology,Division of Biology and Biological Engineering,1200 E.California Boulevard,Pasadena,CA 91125,USA [2]Mammalian Embryo and Stem Cell Group,Department of Physiology,Development,and Neuroscience,University of Cambridge,Cambridge CB23DY,UK [3]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou,325001,Zhejiang,China

出　　处：《The Innovation》2023年第1期20-21,共2页创新（英文）

摘　　要：As embryos,we were extremely lucky to survive implantation,when we transitioned from a simple ball of undifferentiated cells to a complex structure of distinct lineages.During development,fertilization generates a totipotent zygote that ultimately gives rise to themyriad cell types of the whole organism.Inmouse embryos,the first cell fate decision leads to trophectoderm(TE)progenitors on the outside of the early embryo,surrounding the inner cell mass.Epiblast(EPI)and primitive endoderm(PE)cells then arise from the inner cell mass and are initially intermingled(embryonic day 3.5).Thus,themammalian pre-implantation embryo comprises three lineage compartments:TE,destined to become the placenta;PE,destined to become the yolk sac;and EPI,pluripotent cells that will generate the entire body.

关 键 词：IMPLANTATION initially OUTSIDE 

分 类 号：R927.12[医药卫生—药学]