轮状病毒受体结合特征研究进展  

Research progress in the receptor binding characteristics of rotaviruses

作　　者：王铭月 孙晓曼[1] 李丹地[1] Wang Mingyue;Sun Xiaoman;Li Dandi(NHC Key Laboratory of Medical Virology and Viral Diseases,National Institute for Viral Disease Control and Prevention,China CDC,Beijing 102206,China;School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,国家卫生健康委员会医学病毒和病毒病重点实验室,北京102206 [2]甘肃中医药大学公共卫生学院,兰州730000

出　　处：《中华实验和临床病毒学杂志》2022年第6期748-752,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家自然科学基金(21934005)。

摘　　要：轮状病毒(rotavirus,RV)是引起人类和动物急性胃肠炎的重要病原体。结构蛋白VP8*(viral protein 8*,VP8*)位于RV最外层的刺突状VP4的头部,VP8*在受体识别和结合中发挥重要作用。目前对RV受体结合特性的研究主要集中在A组轮状病毒(group A rotavirus,RVA)和C组轮状病毒(group C rotavirus,RVC)。本文对RV的蛋白结构、受体类型以及RVA和RVC受体结合特性及与受体相互作用的结构基础等研究进展进行综述。Rotavirus(RV)is important pathogen causing acute gastroenteritis in humans and animals.Viral protein 8*(VP8*)is located in the head of VP4 in the outermost layer of RV.VP8*plays an important role in receptor recognition and binding.At present,the research on the binding characteristics of RV receptor mainly focuses on group A rotaviruses(RVA)and group C rotaviruses(RVC).This paper reviews the protein structure and receptor types of RV,as well as the receptor binding characteristics of RVA and RVC and the structural basis of their interaction with receptors.

关 键 词：轮状病毒 VP8*蛋白 受体结合特征 

分 类 号：R373[医药卫生—病原生物学]