新生儿铁储备对6月龄婴儿神经发育的影响  

Effect of neonatal iron store on neurodevelopment of 6-month-old infants

作　　者：王静[1] 胡丹丹 张悦 吴志华 马杰 韦茹 WANG Jing;HU Dandan;ZHANG Yue;WU Zhihua;MA Jie;WEI Ru(Department of Children's Health Care,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China;不详)

机构地区：[1]广州市妇女儿童医疗中心儿童保健科,广州510623 [2]广州市妇女儿童医疗中心儿科研究所,广州510623 [3]广州市妇女儿童医疗中心儿童保健与健康管理科,广州510623

出　　处：《实用医学杂志》2023年第1期54-59,共6页The Journal of Practical Medicine

基　　金：广东省中医药局科研项目(编号:20231264);广州市医药卫生科技项目(编号:20181A011029);广州市科技计划项目(编号:202201020648)。

摘　　要：目的探讨新生儿铁储备对6月龄婴儿神经发育的影响。方法连续性收集2016年11月至2018年1月出生的新生儿及其父母129对。用酶联免疫吸附法测定脐血铁蛋白、C反应蛋白、α1酸性糖蛋白。根据脐血铁蛋白浓度将婴儿分为铁蛋白充足、不足和缺乏3组。采用标准问卷收集研究对象的基本资料,采用Gesell发育诊断量表在婴儿6月龄时行发育评估。比较不同脐血铁蛋白水平婴儿6月龄时在神经发育上的差异。结果新生儿脐血铁蛋白平均浓度为(75.3±45.0)μg/L,其中铁蛋白缺乏22例(17.1%),铁蛋白不足54例(41.9%)。脐血铁蛋白充足、不足和缺乏3组婴儿6月龄时在适应性及大动作行为评分达标率的差异有统计学意义(P<0.05)。铁蛋白充足组与缺乏组在适应性和大动作行为评分达标率的差异有统计学意义(P<0.05)。结论铁蛋白不足和缺乏在新生儿中普遍存在,脐血铁蛋白充足的新生儿6月龄时在适应性及大动作行为评分的达标率比脐血铁蛋白缺乏的更高,孕期铁营养及新生儿铁储备状况值得进一步关注。Objective To investigate the effect of neonatal iron store on neurodevelopment of infants aged6 months.Methods A total of 129 neonates born from November 2016 to January 2018 were prospectively selected.Cord blood ferritin,C-reactive protein andα1 acid glycoprotein were detected by enzyme-linked immunosorbent assay.According to the ferritin concentration in the cord blood,the neonates were divided into three groups:sufficient,insufficient and deficient.Standard questionnaire was used to collect the data of parents and infants,and Gesell developmental diagnostic scale was used for evaluation of their neurodevelopment,with a follow-up of 6months.The groups were compared in terms of the neurodevelopment.Results The average ferritin concentration of cord blood was(75.3±45.0)μg/L,including 22 cases(17.1%)in the ferritin deficient group and 54 cases(41.9%)in the ferritin insufficient group.At 6 months of age,there were significant differences in the normal rates of adaptability and gross motor among the 3 groups(P<0.05).There were significant differences in the normal rates of adaptability and gross motor between the ferritin deficient and sufficient group(P<0.05).Conclusion Ferritin deficiency and insufficiency are common in neonates.The proportion of newborns with cord blood ferritin sufficient to achieve normal scores in adaptability and gross motor at 6 months of age is higher than that of neonates with cord blood ferritin deficient.Iron nutrition during pregnancy and iron store in neonates deserves further attention.

关 键 词：脐血 铁蛋白 婴儿 神经发育 

分 类 号：R722.19[医药卫生—儿科]