急性冠状动脉综合征患者残余胆固醇水平与冠状动脉狭窄严重程度的相关性  

Correlation between remnant cholesterol levels and the severity of coronary artery stenosis in patients with ACS

作　　者：巨名飞[1] 刘超[1] 刘佳梅[1] 邵文革 刘婷婷 赵娟[2] JU Mingfei;LIU Chao;LIU Jiamei;SHAO Wen'ge;LIU Tingting;ZHAO Juan(Department of Emergency Medicine,Chengde Medical College Affiliated Hospital,Chengde 067000,China;不详)

机构地区：[1]承德医学院附属医院急诊科,河北承德067000 [2]承德医学院病理生理学教研室,河北承德067000

出　　处：《实用医学杂志》2023年第1期71-75,共5页The Journal of Practical Medicine

基　　金：河北省自然科学基金资助面上项目(编号:H2020406011);承德市科技计划项目(编号:202204A028)。

摘　　要：目的探讨残余胆固醇水平(RC)与急性冠状动脉综合征(ACS)患者冠状动脉狭窄严重程度的相关性,评估RC对ACS患者冠状动脉狭窄程度的预测价值。方法纳入2019年4月至2020年3月于承德医学院附属医院心脏内科诊治的ACS患者共376例,依据冠状动脉造影Gensini评分结果分为轻度狭窄组(Gensini<36分)和中重度狭窄组(Gensini≥36分),比较两组临床基础资料和血脂情况。采用二元多因素logistic分析RC水平与冠状动脉狭窄严重程度的相关性,ROC曲线预测RC对ACS患者冠状动脉狭窄程度的准确度。结果本研究在单变量分析中,ACS患者冠状动脉狭窄严重程度的常见危险因素男性、吸烟、高血压、糖尿病在两组间有显著差异。与轻度狭窄组比较,中重度狭窄组患者TG、non-HDL-C、RC、LDL-C、HDL-C、ALB、CRE水平差异有统计学意义(P<0.05)。经二元多因素logistic回归分析显示:高血压、吸烟、糖尿病、HDL-C、non-HDL-C、RC为ACS患者冠状动脉狭窄严重程度的独立危险因素(P<0.05)。ROC曲线显示血清RC预测ACS患者冠状动脉狭窄严重程度曲线下面积为0.733。结论RC与ACS患者冠状动脉血管狭窄程度呈正相关,RC可成为预测冠状动脉狭窄程度的早期筛查指标。Objective Explore the correlation between levels of remnant cholesterol(RC)and the severity of coronary artery stenosis in patients with acute coronary syndromes(ACS),and evaluate the predictive value of RC on the degree of coronary artery stenosis in patients with ACS.Methods A total of 376 ACS patients treated in the department of cardiology of the Affiliated Hospital of Chengde Medical University from April 2019 to March 2020 are divided into two groups,namely,the mild stenosis(Gensini<36)group and the moderate to severe stenosis group(Gensini≥36)according to the score results of coronary arteriography Gensini.Meanwhile,basic clinical data and blood lipids of the two are compared.Besides,the analyze-regression-binary logistic method is used to analyze the correlation between RC levels and coronary artery stenosis severity,while the ROC curve is employed to predict the accuracy of RC on the degree of coronary stenosis in patients with ACS.Results In the single variable analysis of this study,common risk factors for the severity of coronary artery stenosis among ACS patients like men,cigarette smoking,hypertension,and diabetes mellitus,vary significantly between the two groups.Compared with the mild stenosis group,the level difference of TG,non-HDL-C,RC,LDL-C,HDL-C,ALB and CRE in the moderate to severe stenosis group(P<0.05)is statistically significant.Through AnalyzeRegression-binary logistic,it is revealed that hypertension,cigarette smoking,diabetes mellitus,HDL-C,nonHDL-C,and RC are the independent risk factors for the severity of coronary artery stenosis in ACS patients(P<0.05).The ROC curve shows the area under the coronary stenosis severity curve of serum RC prediction in ACS patients of 0.733.Conclusion RC is positively correlated with the degree of coronary artery vascular stenosis in ACS patients,and RC can be an early screening indicator to predict the degree of coronary artery stenosis.RC,which is positively correlated with the degree of coronary artery vascular stenosis in ACS patients,can be turn

关 键 词：急性冠脉综合征 冠状动脉狭窄严重程度 血脂 残余胆固醇 

分 类 号：H541.4[语言文字]