基于数据挖掘和网络药理学的钱乙治疗小儿惊风用药规律探究  

Study on the Medication Rules of QIAN Yi in Treating Infantile Convulsion Based on Data Mining and Network Pharmacology

作　　者：刘妍琪 郭昱宁 杨帆倩 陈锦芳 谢伟[1] 周鹏[1] LIU Yanqi;GUO Yuning;YANG Fanqian;CHEN Jinfang;XIE Wei;ZHOU Peng(School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中医学院,天津301617 [2]天津中医药大学中药学院,天津301617

出　　处：《中医药导报》2023年第1期130-134,165,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：天津市教委科研计划项目基金资助课题(2018KJ042)。

摘　　要：目的:采用数据挖掘及网络药理学方法探讨钱乙治疗小儿惊风的用药规律。方法:从《小儿药证直诀》中筛选处方48首,经规范化处理后建立数据库,应用Excel 2019、Cytoscape3.8.2、SPSS Modeler 18.0及SPSS Statistics 21.0软件进行频数分析、网络可视化分析、关联规则分析和聚类分析。再通过TCMSP平台和TCMID平台获得药物中所含的化合物,运用Cytoscape3.8.2软件分析和预测重要的药物和化合物。结果:共获得治疗小儿惊风药物105味,以草木、无毒药居多,玉石、有毒药次之;性味以苦寒为主,辛甘温次之,归经以肝、肺、胃经为主,心和脾经次之,剂型以丸、散、膏剂内服为主。Cytoscape3.8.2软件分析得出度值排名前10的药物为麻黄、甘草、天麻、全蝎、蟾蜍、牵牛子、天南星、人参、大黄、半夏,度值排名前5的成分为β-谷甾醇、谷甾醇、植物甾醇、山奈酚、亚油酸乙酯。结论:《小儿药证直诀》中治疗惊风多以治风、豁痰、解热、通腑为基本治则,涉及药物以平肝息风药、开窍药、化痰止咳平喘药、泻下药为主,符合小儿惊风现代治疗的基本思路,重要的药物和化合物经现代研究证实具有抗惊厥、镇静功效,可为小儿惊风的临床治疗和药物研发提供文献依据和理论参考。Objective:To explore the medication rules of QIAN Yi in the treatment of infantile convulsion by data mining and network pharmacology.Methods:48 prescriptions were screened from Key to Therapeutics of Children's Diseases,and a database was established after standardized treatment.Excel 2019,Cytoscape 3.8.2,SPSS Modeler 18.0 and SPSS Statistics 21.0 software were used for frequency analysis,network visualization analysis,association rule analysis and cluster analysis.The compounds contained in the drugs were obtained through the TCMSP platform and the TCMID platform.Cytoscape 3.8.2 software was used to analyze and predict important drugs and compounds.Results:A total of 105 drugs for the treatment of infantile convulsion were obtained,most of which were botanical and non-toxic drugs,followed by jade and toxic drugs.The main natures and flavors were bitter and cold,followed by pungent,sweet,and warm.The meridians were mainly liver,lung and stomach,followed by heart and spleen.The formula preparations were mostly pills,powder,and pasty.Cytoscape 3.8.2 software analysis showed that the top 10 drugs of highest degree value were Mahuang(Ephedrae Herba),Gancao(Glycyrrhizae Radix),Tianma(Gastrodiae Rhizoma),Quanxie(Scorpio),Chanchu(Bufo Siccus),Qianniuzi(Pharbitidis Semen),Tiannanxing(Arisaematis Rhizoma),Renshen(Ginseng Radix),Dahuang rhubarb(Rhei Radix et Rhizoma),and Banxia(Pinelliae Rhizoma).The top 5 components of highest degree value wereβ-sitosterol,sitosterol,phytosterin,kaempferol and ethyl linoleate.Conclusion:The treatment of infantile convulsions in Key to Therapeutics of Children's Diseases is mostly based on the basic principles of dispelling wind,eliminating phlegm,relieving fever and dredging the bowels.The drugs involved are mainly calming liver to stop endogenous wind medicines,resuscitation medicines,antiasthmatic medicines for relieving phlegm and relieving cough,and precipitating medicines,which are in line with the basic ideas of modern treatment of infantile convulsions.The high-frequency Chinese

关 键 词：钱乙 《小儿药证直诀》 惊风 数据挖掘 网络药理学 用药规律 

分 类 号：R272.3[医药卫生—中医儿科学]