三维斑点追踪成像评价射血分数保留的家族性高胆固醇血症患者左心室收缩功能  

Evaluation of Left Ventricular Systolic Function in Patients with Familial Hypercholesterolemia with Preserved Ejection Fraction via Three-Dimensional Speckle Tracking Imaging

作　　者：薛捷文 王宇萍 高娜 汪佳娜 万富鑫 王琴[2] XUE Jiewen;WANG Yuping;GAO Na;WANG Jiana;WAN Fuxin;WANG Qin(Department of Echocardiography in Heart Center,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学临床医学院,宁夏银川750004 [2]宁夏医科大学总医院超声心动图功能检查部,宁夏银川750004

出　　处：《中国医学影像学杂志》2023年第1期30-33,48,共5页Chinese Journal of Medical Imaging

摘　　要：目的应用三维斑点追踪成像(3D-STI)评价射血分数保留的家族性高胆固醇血症(FH)患者左心室收缩功能。资料与方法本研究资料来自北京安贞医院FH疾病筛查与研究的宁夏地区数据,筛选出24例FH,选取宁夏医科大学总医院同期健康体检的30例健康成年人作为对照组。两组均行常规经胸超声心动图和3D-STI检查,收集总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)等,以及左心室常规指标和左心室整体纵向应变(GLS)、整体圆周应变(GCS)、整体径向应变(GRS),比较两组上述指标的差异,采用Pearson相关分析LDL-C与GLS、GRS、GCS及LVEF的相关性。结果FH组的TC和LDL-C明显高于对照组(t=7.748、8.796,P<0.01),HDL-C明显低于对照组(t=8.226,P<0.01)。FH组与对照组左心室常规指标比较,差异均无统计学意义(P>0.05)。FH组的GLS、GCS及GRS明显低于对照组,差异有统计学意义(t=5.701、3.500、4.703,P均<0.01)。FH组LDL-C与GLS、GCS、GRS均呈负相关(r=-0.516、-0.565、-0.586,P均<0.01),但与LVEF无相关性(r=0.237,P=0.265)。结论3D-STI可早期反映FH患者左心室收缩功能改变,较常规经胸超声心动图具有明显的优越性。Purpose To evaluate the left ventricular systolic function in patients with familial hypercholesterolemia(FH)with preserved ejection fraction via three-dimensional speckle tracking imaging(3D-STI).Materials and Methods This study participated in Beijing Anzhen Hospital study of screening FH disease in Ningxia area.Twenty-four patients with FH were selected,and 30 healthy adults who underwent physical examination in General Hospital of Ningxia Medical University in the same period were selected as the healthy control group.Routine transthoracic echocardiography and 3D-STI examination were all performed in both groups to obtain left ventricular routine index,including global longitudinal strain(GLS),global circumferential strain(GCS)and global radial strain(GRS).The laboratory indexes,including total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and triglyceride(TG)were recorded.The differences of all parameters between the two groups were all compared,and Pearson correlation analysis was performed to evaluate the correlation between LDL-C and GLS,GRS,GCS,LVEF,respectively.Results TC and LDL-C in FH group were significantly higher than those in the control group(t=7.748,8.796,P<0.01),while HDL-C was significantly lower than that in the control group(t=8.226,P<0.01).There was no significant difference in left ventricular routine indexes between FH group and control group(P>0.05).The levels of GLS,GCS and GRS in FH group were significantly lower than those in the control group(t=5.701,3.500,4.703,P<0.01).LDL-C in FH group was negatively correlated with GLS,GCS and GRS(r=-0.516,-0.565,-0.586,all P<0.01),but there was no correlation with LVEF(r=0.237,P=0.265).Conclusion 3D-STI can reflect the changes of left ventricular systolic function in patients with FH at an early stage,which has obvious advantages over conventional transthoracic echocardiography.

关 键 词：家族性高胆固醇血症 超声心动描记术 经胸 斑点追踪成像 低密度脂蛋白 心室功能 左 

分 类 号：R445.2[医药卫生—影像医学与核医学] R541[医药卫生—诊断学]