JAK-STAT信号通路与玫瑰痤疮  

JAK-STAT signaling pathway and rosacea

作　　者：王亚玲 谢红付[1] 李吉[1] 汪犇 Wang Yaling;Xie Hongfu;Li Ji;Wang Ben(Department of Dermatology,Xiangya Hospital,Central South University,National Clinical Research Center for Geriatric Disorders(Xiangya),Changsha 410008,China)

机构地区：[1]中南大学湘雅医院皮肤科、国家老年疾病临床医学研究中心(湘雅),长沙410008

出　　处：《中华皮肤科杂志》2023年第2期169-172,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81974480)。

摘　　要：研究表明玫瑰痤疮与炎症因子、神经脉管功能、微生态环境等多种因素有关。JAK-STAT信号通路涉及多种炎症细胞因子,在细胞增殖、分化、凋亡和血管生成及免疫调节等方面发挥重要作用。本文将概述JAK-STAT信号通路并探讨其在玫瑰痤疮中的潜在作用。Studies have shown that rosacea is related to inflammatory factors,neurovascular function,micro-ecological environment and other factors.The Janus kinase(JAK)-signal transducer and activator of transcription(STAT)signaling pathway involves a variety of inflammatory cytokines,and plays an important role in cell proliferation,differentiation,apoptosis,angiogenesis and immune regulation.This review summarizes the JAK-STAT signaling pathway and explores its potential role in rosacea.

关 键 词：红斑痤疮 信号传导 新生血管化 病理性 JAK-STAT信号通路 炎症因子 抗菌肽 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]