盐酸羟考酮联合芬太尼在手术患者术后自控镇痛中的应用效果  

Effectiveness of oxycodone hydrochloride combined with fentanyl in postoperative patient-controlled analgesia

作　　者：刘曼 吴珊 赵森[1] Liu Man;Wu Shan;Zhao Sen(Pharmacy Department,The Affiliated Zhongshan Hospital of Dalian University,Dalian Liaoning 116000,China)

机构地区：[1]大连大学附属中山医院药剂科,辽宁大连116000

出　　处：《保健医学研究与实践》2022年第12期33-36,共4页Health Medicine Research and Practice

摘　　要：目的 探讨盐酸羟考酮联合芬太尼在手术患者术后自控镇痛中的应用效果,以期为临床治疗提供参考。方法 选取2019年4月—2020年12月在大连大学附属中山医院行腹腔镜手术治疗的120例患者作为研究对象。采用随机数字表法将患者分为对照组和观察组,各60例。对照组患者采用芬太尼进行术后自控镇痛。观察组患者在对照组基础上联用盐酸羟考酮进行自控镇痛。比较2组患者术后3 h、24 h、48 h时视觉模拟评分(VAS)、镇静评分系统(RSS)评分及5-羟色胺(5-HT)、P物质(SP)水平。比较2组患者PCA按压次数。比较2组患者自控镇痛期间不良反应总发生率。结果 观察组患者术后3 h、24 h、48 h时VAS评分均低于对照组,差异均有统计学意义(P<0.05)。术后3 h、24 h、48 h时,2组患者RSS评分比较,差异无统计学意义(P>0.05)。观察组患者PCA按压次数少于对照组,差异有统计学意义(P<0.05)。诱导前,2组患者SP、5-HT水平比较,差异无统计学意义(P>0.05)。术后3 h、24 h、48 h时,观察组患者SP、5-HT水平低于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论在手术患者术后自控镇痛中应用盐酸羟考酮联合芬太尼,其镇痛效果明显,可控制机体血清致痛物质水平,且不良反应发生率低,值得推广应用。Objective This paper aims to investigate the effectiveness of oxycodone hydrochloride combined with fentanyl in patient-controlled analgesia(PCA) after surgery to provide a reference for clinical treatment.Methods A total of 120 patients who underwent laparoscopic surgery in the Affiliated Zhongshan Hospital of Dalian University from April 2019 to December 2020 were selected as the study participants.They were assigned to a control group(n=60) and an observation group(n=60) by random number table.Patients in the control group received postoperative PCA with fentanyl.Patients in the observation group received oxycodone hydrochloride for PCA on the basis of the treatment in the control group.The Visual Analogue Scale(VAS),Ramsay Sedation Scale(RSS) score,serotonin(5-hydroxytryptamine,5-HT),and substance P(SP) levels were compared between the two groups at 3 h,24 h,and 48 h after operation.The number of PCA compressions was compared between the 2 groups.The total incidence of adverse reactions during PCA was compared between the 2groups.Results The VAS scores at 3 h,24 h,and 48 h after operation in the observation group were significantly lower than those in the control group(P<0.05).No significant difference in the RSS score was observed between the two groups at 3 h,24 h,and 48 h after operation(P>0.05).Patients in the observation group had significantly fewer PCA compressions than those in the control group(P<0.05).Before induction,there was no significant difference in SP and 5-HT levels between the 2 groups(P>0.05).SP and 5-HT levels in the observation group at 3 h,24 h,and 48 h after operation were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion The application of oxycodone hydrochloride combined with fentanyl in postoperative PCA has marked analgesic effects,with timely control of the level of serum paincausing substances and a low incidence of adverse reactions.The

关 键 词：镇痛 盐酸羟考酮 芬太尼 不良反应 

分 类 号：R657.1[医药卫生—外科学]