骆驼宁F一锅全合成的创新型综合实验设计及教学实践  

Teaching of Innovative and Comprehensive Experiment Based on One-Pot Total Synthesis of Luotonin F

作　　者：吴彦东 费峥 邱明强[1] 黄纯 吴安心[1] WU Yan-Dong;FEI Zheng;QIU Ming-Qiang;HUANG Chun;WU An-Xin(College of Chemistry,Central China Normal University,Wuhan 430079,China)

机构地区：[1]华中师范大学化学学院,湖北武汉430079

出　　处：《化学教育（中英文）》2023年第2期55-61,共7页Chinese Journal of Chemical Education

基　　金：国家自然科学基金项目(21971079);中央高校基本科研业务费专项资金(科研成果转化实验教学内容)项目(CCNU19KYZHSY10)。

摘　　要：基于天然产物骆驼宁F一锅全合成的相关科研成果,利用本科生创新型综合实验平台,设计了从简单易得的底物出发,在较温和的条件下实现天然产物骆驼宁F一锅全合成的创新型综合化学实验。该实验将自组织一锅全合成的前沿理论知识应用到骆驼宁F的全合成之中,实验内容包括文献调研及分析总结、骆驼宁F一锅全合成、化合物波谱学性质检测分析以及反应过程学研究等部分。该实验可以显著提高学生对于有机合成方法学及反应过程学研究方式的理解,使其掌握相关实验操作技术及核磁等大型仪器的检测原理和操作技能,培养学生的文献检索、路线设计、合成操作以及谱图分析等方面的综合能力,提升学生的科学研究兴趣及独立思考解决问题的创新意识。Based on the research result of the one-pot total synthesis of natural product Luotonin F, and with the assistance of undergraduate innovative comprehensive experimental platform, the one-pot total synthesis of natural product Luotonin F from simple and readily available substrates was investigated under mild conditions. This experiment transformed the frontier theoretical knowledge of self-directed one-pot synthesis into the total synthesis of Luotonin F. The experiment includes four parts: Literature investigation and analysis, one-pot total synthesis of Luotonin F, spectral data processing and mechanism study. The results show that this teaching practice can significantly improve the students’ understanding of the research method of organic synthesis and mechanism study. Moreover, the systematic experimental procedure can help students to master the relevant experimental operating techniques, and the testing principles and operating skills of large-scale instruments such as nuclear magnetic resonance. students’ comprehensive quality in literature retrieval, synthesis route design, synthesis operation, and spectra analysis will be trained in this experiment. Their interests in scientific research and innovative consciousness of solving problems independently can be further enhanced.

关 键 词：创新型综合化学实验 骆驼宁F 一锅全合成 综合能力 

分 类 号：O629-4[理学—有机化学] G642.423[理学—化学]